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Oxford Nanopore Technologies plc

Company type	Public limited company
Traded as	LSE: ONT
ISIN	GB00BP6S8Z30
Industry	Nanopore sequencing
Founded	2005; 20 years ago (2005)
Founders	Hagan Bayley Gordon Sanghera Spike Willcocks
Headquarters	Oxford Science Park, Oxford, United Kingdom
Key people	Duncan Tatton-Brown (Chair) Gordon Sanghera (CEO)
Revenue	£169.7 million (2023)
Operating income	£(168.7) million (2023)
Net income	£(154.5) million (2023)
Website	nanoporetech.com

Oxford Nanopore Technologies plc is a UK-based company which develops and sells nanopore sequencing products (including the portable DNA sequencer, MinION) for the direct, electronic analysis of single molecules. It is listed on the London Stock Exchange and is a constituent of the FTSE 250 Index.

History

The company was founded in 2005 as a spin-out from the University of Oxford by Hagan Bayley, Gordon Sanghera, and Spike Willcocks, with seed funding from the IP Group. The company made an initial public offering on the London Stock Exchange on 30 September 2021, under the ticker ONT.

In March 2016 the company announced a chemistry upgrade to its nanopore sequencing product 'R9', using a protein nanopore in collaboration with the laboratory of Han Remaut (VIB/Vrije Universiteit Brussel). The company stated in a webcast that R9 is designed to improve error rates and yield.

In July 2016, a MinION nanopore sequencer was included on the ninth NASA/SpaceX commercial cargo resupply services mission to the International Space Station. The aim of the mission was to provide proof of concept for the MinION's functionality in a microgravity environment. During the mission, ISS crew members successfully sequenced DNA from bacteria, bacteriophage and rodents from samples prepared on Earth. Maintaining the MinION device as a research facility on the space station holds the potential to support a number of additional science investigations, any of which could have Earth based applications.

Products

The main products of Oxford Nanopore are:

• MinION: this harmonica-sized portable protein nanopore sequencing USB device has been commercially available since May 2015 after having been launched initially through an early access program, the MinION Access Program (MAP).
• GridION X5: this desktop device has been commercially available since March 2017. The device processes up to five MinION Flow Cells and enables generation of up to 100 Gb of data per run.
• PromethION: this desktop, high throughput device will be available through an access program that opened for registration in July 2015. The device contains channels for 144,000 nanopores (in comparison to MinION’s 512).
• VolTRAX: this device is designed for automated sample preparation so that users do not need a laboratory or lab skills to run the device. Registration for the early access program was opened in October 2016.
• Metrichor: this spinout company from Oxford Nanopore was set up to provide end to end solutions for biological analyses, using nanopore sensing technologies.
• SmidgION: a mobile phone sequencer announced in May 2016, currently in development.

These products are intended to be used for the analysis of DNA, RNA, proteins and small molecules with a range of applications in personalized medicine, crop science, and scientific research.

References

1. ^ "Annual Results for year ended 31 December 2023" (PDF). Oxford Nanopore Technologies. Retrieved 4 September 2024.
2. Eisenstein, M. (2012). "Oxford Nanopore announcement sets sequencing sector abuzz". Nature Biotechnology. 30 (4): 295–6. doi:10.1038/nbt0412-295. PMID 22491260. S2CID 205267199.
3. ^ Mikheyev, A. S.; Tin, M. M. Y. (2014). "A first look at the Oxford Nanopore MinION sequencer". Molecular Ecology Resources. 14 (6): 1097–102. doi:10.1111/1755-0998.12324. PMID 25187008. S2CID 3674911.
4. Loman, N. J.; Quinlan, A. R. (2014). "Poretools: A toolkit for analyzing nanopore sequence data". Bioinformatics. 30 (23): 3399–401. doi:10.1093/bioinformatics/btu555. PMC 4296151. PMID 25143291.
5. "FTSE UK Index Series Quarterly Review December 2024". FTSE Russell. 4 December 2024. Retrieved 20 December 2024.
6. "BAYLEY, Prof. (John) Hagan (Pryce)". Who's Who. Vol. 2015 (online edition via Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
7. "DNA sequencing: The hole story". The Economist. London. 16 October 2008. Retrieved 19 October 2014.
8. "London Stock Exchange welcomes Oxford Nanopore Technologies plc to the Main Market". 11 October 2021.
9. "VIB announces collaboration with Oxford Nanopore Technologies on new DNA sequencing nanopore". Retrieved 9 May 2016.
10. "No thanks, I've already got one". YouTube. Retrieved 9 May 2016.
11. Ramsey, Sarah (21 June 2016). "Next SpaceX Commercial Cargo Launch Now No Earlier Than July 18". Retrieved 25 July 2016.
12. "Sequencing DNA in Space - SpaceRef". spaceref.com. Retrieved 25 July 2016.
13. Rainey, Kristine (29 August 2016). "First DNA Sequencing in Space a Game Changer". NASA. Retrieved 17 October 2016.
14. McIntyre, Alexa B. R.; Rizzardi, Lindsay; Yu, Angela M.; Rosen, Gail L.; Alexander, Noah; Botkin, Douglas J.; John, Kristen K.; Castro-Wallace, Sarah L.; Burton, Aaron S. (10 December 2015). "Nanopore Sequencing in Microgravity". bioRxiv 10.1101/032342.
15. Check Hayden, E. (2014). "Data from pocket-sized genome sequencer unveiled". Nature. doi:10.1038/nature.2014.14724.
16. Check Hayden, E. (2015). "Pint-sized DNA sequencer impresses first users". Nature. 521 (7550): 15–6. Bibcode:2015Natur.521...15C. doi:10.1038/521015a. PMID 25951262.
17. "IP Group PLC – Portfolio company Oxford Nanopore announces £70m fundraising – IP Group PLC". Archived from the original on 21 November 2015. Retrieved 20 November 2015.
18. Loman, Nicholas J; Watson, Mick (2015). "Successful test launch for nanopore sequencing". Nature Methods. 12 (4): 303–304. doi:10.1038/nmeth.3327. ISSN 1548-7091. PMID 25825834. S2CID 5604121.
19. "Oxford Nanopore Launches GridIon X5 Nanopore Sequencer, Details Product Improvements". GenomeWeb. Retrieved 6 July 2017.
20. "GridION X5". nanoporetech.com. Retrieved 6 July 2017.
21. "Community - Oxford Nanopore Technologies". Archived from the original on 27 June 2015. Retrieved 17 June 2015.
22. "Specifications - Community - Oxford Nanopore Technologies". Archived from the original on 1 June 2016. Retrieved 20 November 2015.
23. "Oxford Nanopore CTO Clive Brown's Talk at London Calling: MinION ASIC, volTRAX, promethION". Next Gen Seek. 14 May 2015.
24. "VolTRAX". nanoporetech.com. Retrieved 17 October 2016.
25. "Oxford Nanopore: we want to create the internet of living things". Wired UK.
26. "Metrichor". metrichor.com. Retrieved 17 August 2016.
27. "SmidgION - Products & services - Oxford Nanopore Technologies". www2.nanoporetech.com. Archived from the original on 23 August 2016. Retrieved 17 August 2016.
28. Check Hayden, Erika (2012). "Nanopore genome sequencer makes its debut". Nature. doi:10.1038/nature.2012.10051. ISSN 1744-7933.

External links

• Oxford Nanopore Technologies Website

• Companies in the FTSE 250 Index
• British companies established in 2005
• Companies based in Oxford
• Genomics companies
• Technology companies established in 2005
• Companies listed on the London Stock Exchange