Mossi is an Italian surname that may refer to the following notable people:
- Anthony Mossi (born 1994), French football goalkeeper
- Dante Mossi, Honduran economist, international civil servant and diplomat
- Don Mossi (1929–2019), American baseball player
- Giovanni Mossi (c.1680–1742), Italian composer
- Hafsa Mossi (1964–2016), Burundian politician and journalist
- Juma Mossi (born 1973), Burundian football player
- Luigi De Mossi (born 1960), Italian politician and lawyer
- Trésor Mossi (born 2001), Burundian footballer
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