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Motile sperm domain containing 2

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Protein-coding gene in the species Homo sapiens
MOSPD2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WIC

Identifiers
AliasesMOSPD2, Motile sperm domain containing 2
External IDsMGI: 1924013; HomoloGene: 22125; GeneCards: MOSPD2; OMA:MOSPD2 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)
X chromosome (human)Genomic location for MOSPD2Genomic location for MOSPD2
BandXp22.2Start14,873,421 bp
End14,922,327 bp
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)
X chromosome (mouse)Genomic location for MOSPD2Genomic location for MOSPD2
BandX|X F5Start163,719,165 bp
End163,763,371 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • corpus callosum

  • inferior ganglion of vagus nerve

  • monocyte

  • C1 segment

  • subthalamic nucleus

  • visceral pleura

  • blood

  • decidua

  • Pons
Top expressed in
  • parotid gland

  • Epithelium of choroid plexus

  • carotid body

  • ciliary body

  • sciatic nerve

  • iris

  • left lung lobe

  • conjunctival fornix

  • seminal vesicula

  • calvaria
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

158747

76763

Ensembl

ENSG00000130150

ENSMUSG00000061778

UniProt

Q8NHP6

Q9CWP6

RefSeq (mRNA)

NM_001177475
NM_152581
NM_001330241

NM_001290523
NM_001290524
NM_029730

RefSeq (protein)

NP_001170946
NP_001317170
NP_689794

NP_001277452
NP_001277453
NP_084006

Location (UCSC)Chr X: 14.87 – 14.92 MbChr X: 163.72 – 163.76 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Motile sperm domain containing 2 is a protein that in humans is encoded by the MOSPD2 gene. It is an endoplasmic reticulum–resident protein involved in membrane contact site formation. Its domain homologous to Major Sperm Protein (MSP domain) is very similar to VAPA/VAPB, so it has been described as the third human member of the VAP protein family.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000130150 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000061778 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Motile sperm domain containing 2".
  6. Di Mattia T, Wilhelm LP, Ikhlef S, Wendling C, Spehner D, Nominé Y, Giordano F, Mathelin C, Drin G, Tomasetto C, Alpy F (June 2018). "Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites". EMBO Reports. 19 (7): e45453. doi:10.15252/embr.201745453. PMC 6030701. PMID 29858488.

Further reading

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Motile sperm domain-containing protein 2
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