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Murid gammaherpesvirus 68
Virus classification
(unranked):	Virus
Realm:	Duplodnaviria
Kingdom:	Heunggongvirae
Phylum:	Peploviricota
Class:	Herviviricetes
Order:	Herpesvirales
Family:	Orthoherpesviridae
Genus:	Rhadinovirus
Species:	Murid gammaherpesvirus 4
Virus:	Murid gammaherpesvirus 68

Murid gammaherpesvirus 68 (MuHV-68) is an isolate of the virus species Murid gammaherpesvirus 4, a member of the genus Rhadinovirus. It is a member of the subfamily Gammaherpesvirinae in the family of Herpesviridae. MuHV-68 serves as a model for study of human gammaherpesviruses which cause significant human disease including B-cell lymphoma and Kaposi's sarcoma. The WUMS strain of MuHV-68 was fully sequenced and annotated in 1997, and the necessity of most of its genes in viral replication was characterized by random transposon mutagenesis.

Surface proteins

Alpha-, beta-, and gammaherpesviruses display a heterodimer composed of glycoprotein H (gH) and glycoprotein L (gL) on their envelopes. This receptor is involved in the cell-to-cell transmission of the virus. Glycoprotein H has two conformations. Glycoprotein L is a chaperone protein which assures that gH takes on the correct conformation. Murid gammaherpesvirus 68 lack gL, gH misfolds. When alpha- or betaherpesviruses lack gL, they are noninfectious. Murid gammaherpesvirus 68 lacks gL, it remains infectious but is less able to bind to fibroblasts and epithelial cells.

The open reading frame M7 of the MuHV-68 genome encodes for the surface receptor glycoprotein 150 (gp150). It is homologous to the Epstein-Barr virus membrane antigen gp350/220. MuHV-68 is more closely related to the Kaposi's Sarcoma-associated herpesvirus (KSHV) than it is to the Epstein-Barr virus. Glycoprotein K8.1 is the KSHV homolog of MuHV-68 gp150. MuHV-68 is a very close relative of MuHV-72. The MuHV-68 M7 gene differs from the corresponding MuHV-72 gene by five point mutations which alter four codons. Glycoprotein 150 allows MuHV-68 to bind to B-cells.

References

1. Herbet W. Virgin IV; Philip Latreille; Pamela Wamsley; Kymberlie Hallsworth; Karen E. Weck; Albert J. Dal Canto & Samuel H. Speck (August 1997). "Complete sequence and genomic analysis of murine gammaherpesvirus 68". Journal of Virology. 71 (8): 5894–904. doi:10.1128/JVI.71.8.5894-5904.1997. PMC 191845. PMID 9223479.
2. Moon Jung Song; Seungmin Hwang; Wendy H. Wong; Ting-Ting Wu; Sangmi Lee; Hsiang-I Liao & Ren Sun (March 2005). "Identification of viral genes essential for replication of murine γ-herpesvirus 68 using signature-tagged mutagenesis". Proceedings of the National Academy of Sciences of the United States of America. 102 (10): 3805–10. Bibcode:2005PNAS..102.3805S. doi:10.1073/pnas.0404521102. PMC 553290. PMID 15738413.
3. Laurent Gillet; Janet S. May; Susanna Colaco & Philip G. Stevenson (January 2007). "Glycoprotein L Disruption Reveals Two Functional Forms of the Murine Gammaherpesvirus 68 Glycoprotein H". Journal of Virology. 81 (1): 280–291. doi:10.1128/jvi.01616-06. PMC 1797276. PMID 17050601.
4. ^ Macáková K, Matis J, Rezuchová I, Kúdela O, Raslová H, Kúdelová M (Jan 2003). "Murine gammaherpesvirus (MuHV) M7 gene encoding glycoprotein 150 (gp150): difference in the sequence between 72 and 68 strains". Virus Genes. 26 (1): 89–95. doi:10.1023/a:1022390407991. PMID 12683351. S2CID 34818785.
5. ^ James P. Stewart; Ondine J. Silvia; Isobel M. D. Atkin; David J. Hughes; Bahram Ebrahimi & Heiko Adler (October 2004). "In Vivo Function of a Gammaherpesvirus Virion Glycoprotein: Influence on B-Cell Infection and Mononucleosis". Journal of Virology. 78 (19): 10449–10459. doi:10.1128/jvi.78.19.10449-10459.2004. PMC 516434. PMID 15367611.

v t e Taxonomy of the Herpesvirales
Higher taxonomy: Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales
Malacoherpesviridae	Aurivirus AbHV-1 Ostreavirus OsHV-1
Alloherpesviridae	Batrachovirus RaHV-1 2 3 Cyprinivirus AngHV-1 CyHV-1 2 3 Ictalurivirus AciHV-2 IcHV-1 2 Salmonivirus SalHV-1 2 3
Herpesviridae IgHV-2	α ChHV-6 Iltovirus GaHV-1 PsHV-1 Mardivirus AnHV-1 CoHV-1 GaHV-2 3 MeHV-1 SpAHV-1 Scutavirus ChHV-5 TeHV-3 Simplexvirus AtHV-1 BoHV-2 CeHV-2 HHV-1 2 LeHV-4 McHV-1 2 3 MaHV-1 2 PnHV-3 PaHV-2 PtHV-1 SaHV-1 Varicellovirus BoHV-1 5 BuHV-1 CaHV-1 CpHV-1 CeHV-9 CvHV-1 2 3 EHV-1 3 4 8 9 FeHV-1 HHV-3 MoHV-1 PhHV-1 SuHV-1 β Cytomegalovirus AoHV-1 CbHV-1 CeHV-5 HHV-5 McHV-3 8 MnHV-1 PnHV-2 PaHV-3 4 SaHV-4 Muromegalovirus MuHV-1 2 8 Proboscivirus ElHV-1 4 5 Quwivirus CaHV-2 MschBHV1 TuHV-1 Roseolovirus HHV-6A 6B 7 McHV-9 MuHV-3 SuHV-2 γ EHV-7 PhHV-2 SgHV-1 Bossavirus DeHV-1 Lymphocryptovirus CalHV-3 CeHV-14 GoHV-1 HHV-4 McHV-4 10 PnHV-1 PaHV-1 PoHV-2 Macavirus AlHV-1 2 BoHV-6 CpHV-2 HiHV-1 OvHV-2 SuHV-3 4 5 Manticavirus PhaHV-1 VoHV-1 Percavirus EHV-2 5 FeHV-1 MusHV-1 PhHV-3 VeHV-1 Patagivirus VeHV-3 Rhadinovirus AtHV-2 3 BoHV-4 CrHV-2 HHV-8 McHV-5 8 11 12 MuHV-4 7 SaHV-2
Unassigned species listed below parent taxon –– Source: ICTV –– Wikispecies

• Animal virology
• Gammaherpesvirinae
• Unaccepted virus taxa