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In enzymology, a N-formylglutamate deformylase (EC 3.5.1.68) is an enzyme that catalyzes the chemical reaction

N-formyl-L-glutamate + H₂O ${\displaystyle \rightleftharpoons }$ formate + L-glutamate

Thus, the two substrates of this enzyme are N-formyl-L-glutamate and H₂O, whereas its two products are formate and L-glutamate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-formyl-L-glutamate amidohydrolase. Other names in common use include beta-citryl-L-glutamate hydrolase, formylglutamate deformylase, N-formylglutamate hydrolase, beta-citrylglutamate amidase, beta-citryl-L-glutamate amidohydrolase, beta-citryl-L-glutamate amidase, beta-citrylglutamate amidase, and beta-citryl-L-glutamate-hydrolyzing enzyme. This enzyme participates in histidine metabolism and glyoxylate and dicarboxylate metabolism.

References

• Hu L, Mulfinger LM, Phillips AT (1987). "Purification and properties of formylglutamate amidohydrolase from Pseudomonas putida". J. Bacteriol. 169 (10): 4696–702. PMC 213842. PMID 3308850.
• Miyake M, Innami T, Kakimoto Y (1983). "A beta-citryl-L-glutamate-hydrolysing enzyme in rat testes". Biochim. Biophys. Acta. 760 (2): 206–14. doi:10.1016/0304-4165(83)90165-4. PMID 6414521.

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