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In enzymology, a N-methyl-L-amino-acid oxidase (EC 1.5.3.2) is an enzyme that catalyzes the chemical reaction

an N-methyl-L-amino acid + H₂O + O₂ ${\displaystyle \rightleftharpoons }$ an L-amino acid + formaldehyde + H₂O₂

The 3 substrates of this enzyme are N-methyl-L-amino acid, H₂O, and O₂, whereas its 3 products are L-amino acid, formaldehyde, and H₂O₂.

It has 2 cofactors: FAD, and Flavoprotein.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating). Other names in common use include N-methylamino acid oxidase, and demethylase.

References

Further reading

• Moritani M (1952). "Demethylase. IV. Kinetics and reaction mechanism". Hukuoka Acta Med. 43: 651–658.
• Moritani M (1952). "Demethylase. V. Specificity and its relation to amino acid oxidase". Hukuoka Acta Med. 43: 731–735.
• Moritani M, Tung TC, Fujii S, Mito H, Izumiya N, Kenmochi K, Hirohata R (August 1954). "Specificity of rabbit kidney demethylase". The Journal of Biological Chemistry. 209 (2): 485–92. PMID 13192101.

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