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In enzymology, a N-substituted formamide deformylase (EC 3.5.1.91) is an enzyme that catalyzes the chemical reaction

N-benzylformamide + H₂O ${\displaystyle \rightleftharpoons }$ formate + benzylamine

Thus, the two substrates of this enzyme are N-benzylformamide and H₂O, whereas its two products are formate and benzylamine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-benzylformamide amidohydrolase and is also called NfdA. The enzyme is produced by Arthrobacter pascens bacteria.

References

1. Fukatsu H, Hashimoto Y, Goda M, Higashibata H, Kobayashi M (September 2004). "Amine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloning". Proceedings of the National Academy of Sciences of the United States of America. 101 (38): 13726–31. Bibcode:2004PNAS..10113726F. doi:10.1073/pnas.0405082101. PMC 518824. PMID 15358859.
2. Schomburg D, Schomburg I, Chang A, eds. (2009). "3.5.1.91 N-substituted formamide deformylase". Class 3 Hydrolases: EC 3.4.22-3.13. Springer Handbook of Enzymes (2nd ed.). Springer Science & Business Media. pp. 376–378. ISBN 9783540857051.

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