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N6AMT1

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Protein-coding gene in the species Homo sapiens
N6AMT1
Identifiers
AliasesN6AMT1, C21orf127, HEMK2, MTQ2, N6AMT, m.HsaHemK2P, PRED28, N-6 adenine-specific DNA methyltransferase 1 (putative), N-6 adenine-specific DNA methyltransferase 1, PrmC, KMT9
External IDsOMIM: 614553; MGI: 1915018; HomoloGene: 5637; GeneCards: N6AMT1; OMA:N6AMT1 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)
Chromosome 21 (human)Genomic location for N6AMT1Genomic location for N6AMT1
Band21q21.3Start28,872,191 bp
End28,885,371 bp
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)
Chromosome 16 (mouse)Genomic location for N6AMT1Genomic location for N6AMT1
Band16|16 C3.3Start87,151,073 bp
End87,165,630 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad

  • ventricular zone

  • right uterine tube

  • apex of heart

  • left ovary

  • right adrenal gland

  • right adrenal cortex

  • ganglionic eminence

  • body of uterus
Top expressed in
  • interventricular septum

  • superior cervical ganglion

  • hand

  • genital tubercle

  • yolk sac

  • right kidney

  • spinal ganglia

  • Rostral migratory stream

  • tail of embryo

  • proximal tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29104

67768

Ensembl

ENSG00000156239

ENSMUSG00000044442

UniProt

Q9Y5N5

Q6SKR2

RefSeq (mRNA)

NM_013240
NM_182749

NM_001159331
NM_026366

RefSeq (protein)

NP_037372
NP_877426

NP_001152803
NP_080642

Location (UCSC)Chr 21: 28.87 – 28.89 MbChr 16: 87.15 – 87.17 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

N-6 adenine-specific DNA methyltransferase 1 is a protein that in humans is encoded by the N6AMT1 gene.

Function

The N6AMT1 gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. . N6AMT1 functions as a protein glutamine methyltransferase and is essential for mouse development (Liu et al., Mol. Cell. Biol. 2010).

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000156239Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000044442Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: N-6 adenine-specific DNA methyltransferase 1". Retrieved 2018-08-24.

Further reading

Peng Liu, Song Nie, Bing Li, Zhong-Qiang Yang, Zhi-Mei Xu, Jian Fei, Chyuansheng Lin, Rong Zeng, and Guo-Liang Xu. Deficiency in a Glutamine-Specific Methyltransferase for Release Factor Causes Mouse Embryonic Lethality. MOLECULAR AND CELLULAR BIOLOGY, Sept. 2010, p. 4245–4253 Vol. 30, No. 17 0270-7306/10/

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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