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NABP1
Identifiers
Aliases	NABP1, OBFC2A, SOSS-B2, SSB2, nucleic acid binding protein 1
External IDs	OMIM: 612103; MGI: 1923258; HomoloGene: 57094; GeneCards: NABP1; OMA:NABP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q32.3 Start 191,678,068 bp End 191,741,097 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C1.1 Start 51,505,021 bp End 51,517,584 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte amniotic fluid parietal pleura spleen stromal cell of endometrium epithelium of nasopharynx decidua sperm blood visceral pleura Top expressed in transitional epithelium of urinary bladder thymus seminiferous tubule spermatid right kidney granulocyte brown adipose tissue yolk sac intercostal muscle white adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function single-stranded DNA binding DNA binding protein binding RNA binding Cellular component nucleus nucleoplasm cytosol SOSS complex Biological process response to ionizing radiation double-strand break repair via homologous recombination DNA repair cellular response to DNA damage stimulus snRNA transcription by RNA polymerase II mitotic cell cycle checkpoint signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64859 109019 Ensembl ENSG00000173559 ENSMUSG00000026107 UniProt Q96AH0 Q8BGW5 RefSeq (mRNA) NM_001031716 NM_001254736 NM_022837 NM_028696 NM_001310548 NM_001310549 RefSeq (protein) NP_001026886 NP_001241665 NP_001297477 NP_001297478 NP_082972 Location (UCSC) Chr 2: 191.68 – 191.74 Mb Chr 1: 51.51 – 51.52 Mb PubMed search
Wikidata
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Nucleic acid binding protein 1 is a protein that in humans is encoded by the NABP1 gene.

Function

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000173559 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000026107 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Nucleic acid binding protein 1".
6. Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK (May 2008). "Single-stranded DNA-binding protein hSSB1 is critical for genomic stability". Nature. 453 (7195): 677–81. Bibcode:2008Natur.453..677R. doi:10.1038/nature06883. PMID 18449195. S2CID 4322436.

Further reading

• Li Y, Bolderson E, Kumar R, Muniandy PA, Xue Y, Richard DJ, Seidman M, Pandita TK, Khanna KK, Wang W (August 2009). "HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response". The Journal of Biological Chemistry. 284 (35): 23525–31. doi:10.1074/jbc.C109.039586. PMC 2749126. PMID 19605351.
• Huang J, Gong Z, Ghosal G, Chen J (August 2009). "SOSS complexes participate in the maintenance of genomic stability". Molecular Cell. 35 (3): 384–93. doi:10.1016/j.molcel.2009.06.011. PMC 2756616. PMID 19683501.
• Malovannaya A, Li Y, Bulynko Y, Jung SY, Wang Y, Lanz RB, O'Malley BW, Qin J (February 2010). "Streamlined analysis schema for high-throughput identification of endogenous protein complexes". Proceedings of the National Academy of Sciences of the United States of America. 107 (6): 2431–6. Bibcode:2010PNAS..107.2431M. doi:10.1073/pnas.0912599106. PMC 2823922. PMID 20133760.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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