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NKAP
Identifiers
Aliases	NKAP, NFKB activating protein, MRXSHD
External IDs	OMIM: 300766; MGI: 1914300; HomoloGene: 134325; GeneCards: NKAP; OMA:NKAP - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq24 Start 119,920,672 bp End 119,943,751 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A3.3 Start 36,390,448 bp End 36,414,399 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve gonad monocyte buccal mucosa cell gastrocnemius muscle C1 segment muscle of thigh right adrenal cortex left adrenal gland Top expressed in aortic valve otic placode ascending aorta fossa otic vesicle substantia nigra external carotid artery internal carotid artery condyle supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin DNA binding protein binding RNA binding chromatin binding Cellular component nucleus nucleoplasm cytosol Biological process Notch signaling pathway stem cell population maintenance hematopoietic stem cell proliferation hemopoiesis granulocyte differentiation negative regulation of transcription by RNA polymerase II T cell differentiation in thymus positive regulation of alpha-beta T cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of protein targeting to mitochondrion negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79576 67050 Ensembl ENSG00000101882 ENSMUSG00000016409 UniProt Q8N5F7 Q9D0F4 RefSeq (mRNA) NM_024528 NM_025937 RefSeq (protein) NP_078804 NP_080213 Location (UCSC) Chr X: 119.92 – 119.94 Mb Chr X: 36.39 – 36.41 Mb PubMed search
Wikidata
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NF-kappa-B-activating protein is a protein that in humans is encoded by the NKAP gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000101882 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000016409 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen D, Li Z, Yang Q, Zhang J, Zhai Z, Shu HB (Oct 2003). "Identification of a nuclear protein that promotes NF-kappaB activation". Biochem Biophys Res Commun. 310 (3): 720–4. doi:10.1016/j.bbrc.2003.09.074. PMID 14550261.
6. "Entrez Gene: NKAP NF-kappaB activating protein".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ghiorzo P, Mantelli M, Gargiulo S, et al. (2004). "Inverse correlation between p16INK4A expression and NF-kappaB activation in melanoma progression". Hum. Pathol. 35 (8): 1029–37. doi:10.1016/j.humpath.2004.02.017. PMID 15297971.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034. S2CID 895879.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Zhande R, Karsan A (2007). "Erythropoietin promotes survival of primary human endothelial cells through PI3K-dependent, NF-kappaB-independent upregulation of Bcl-xL". Am. J. Physiol. Heart Circ. Physiol. 292 (5): H2467–74. doi:10.1152/ajpheart.00649.2006. PMID 17237249. S2CID 15775587.

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