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NPAS4
Identifiers
Aliases	NPAS4, Le-PAS, NXF, PASD10, bHLHe79, neuronal PAS domain protein 4
External IDs	OMIM: 608554; MGI: 2664186; HomoloGene: 15333; GeneCards: NPAS4; OMA:NPAS4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.2 Start 66,421,004 bp End 66,426,707 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 5,034,383 bp End 5,040,344 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Pituitary Gland anterior pituitary gonad left uterine tube body of uterus muscle layer of sigmoid colon gastric mucosa smooth muscle tissue popliteal artery tibial arteries Top expressed in islet of Langerhans female urethra superior frontal gyrus primary visual cortex prefrontal cortex nucleus accumbens olfactory bulb dentate gyrus of hippocampal formation granule cell neural layer of retina cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein dimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component postsynapse transcription regulator complex nucleus Biological process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated cellular response to corticosterone stimulus positive regulation of transcription by RNA polymerase II transcription, DNA-templated transcription by RNA polymerase II nervous system development learning short-term memory long-term memory cell differentiation regulation of synaptic transmission, GABAergic social behavior regulation of synaptic plasticity excitatory postsynaptic potential inhibitory postsynaptic potential inhibitory synapse assembly regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 266743 225872 Ensembl ENSG00000174576 ENSMUSG00000045903 UniProt Q8IUM7 Q8BGD7 RefSeq (mRNA) NM_178864 NM_001318804 NM_153553 RefSeq (protein) NP_001305733 NP_849195 NP_705781 Location (UCSC) Chr 11: 66.42 – 66.43 Mb Chr 19: 5.03 – 5.04 Mb PubMed search
Wikidata
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Neuronal PAS domain protein 4 is a protein that in humans is encoded by the NPAS4 gene. The NPAS4 gene is a neuronal activity-dependent immediate early gene that has been identified as a transcription factor. The protein regulates the transcription of genes that control inhibitory synapse development, synaptic plasticity and most recently reported also behavior.

Function

NPAS4 is a member of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 )..

NPAS4 has been shown by Dr. Brenda Bloodgood to play critical roles in regulating the plasticity of inhibitory neurons. She found that NPAS4 helps to regulate plasticity by orchestrating a redistribution of inhibitory synapses, wherein they are lost from proximal apical dendrites of CA1 pyramidal neurons and increased on the somata.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000174576 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000045903 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Neuronal PAS domain protein 4". Retrieved 2017-10-15.
6. Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa K, Ahammad RU, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K (2019). "Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors". Cell Reports. 29 (10): 3235–3252.e9. doi:10.1016/j.celrep.2019.10.116. PMID 31801086.
7. Bloodgood BL, Sharma N, Browne HA, Trepman AZ, Greenberg ME (2013-11-07). "The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition". Nature. 503 (7474): 121–125. Bibcode:2013Natur.503..121B. doi:10.1038/nature12743. ISSN 1476-4687. PMC 4169177. PMID 24201284.

Further reading

• Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression". Mol. Cell. Biol. 24 (2): 608–16. doi:10.1128/mcb.24.2.608-616.2004. PMC 343817. PMID 14701734.
• Bersten DC, Bruning JB, Peet DJ, Whitelaw ML (2014). "Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function". PLOS ONE. 9 (1): e85768. Bibcode:2014PLoSO...985768B. doi:10.1371/journal.pone.0085768. PMC 3894988. PMID 24465693.
• Klaric TS, Thomas PQ, Dottori M, Leong WK, Koblar SA, Lewis MD (2014). "A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells". Stem Cell Res Ther. 5 (3): 64. doi:10.1186/scrt453. PMC 4076635. PMID 24887558.
• Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa K, Ahammad RU, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K (2019). "Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors". Cell Reports. 29 (10): 3235–3252.e9. doi:10.1016/j.celrep.2019.10.116. PMID 31801086.

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