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NPB
Identifiers
Aliases	NPB, L7, PPL7, PPneuropeptide B
External IDs	OMIM: 607996; MGI: 2387153; HomoloGene: 102151; GeneCards: NPB; OMA:NPB - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 81,900,745 bp End 81,902,905 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 120,499,303 bp End 120,499,919 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment testicle Hypothalamus substantia nigra nucleus accumbens Amygdala stromal cell of endometrium Brodmann area 9 putamen anterior cingulate cortex Top expressed in stomach embryo testicle morula embryo right kidney spermatid placenta urinary bladder cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding G protein-coupled receptor binding Cellular component extracellular region Biological process neuropeptide signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 256933 208990 Ensembl ENSG00000183979 ENSMUSG00000044034 UniProt Q8NG41 Q8K4P1 RefSeq (mRNA) NM_148896 NM_153288 NM_001347616 NM_001347617 RefSeq (protein) NP_683694 NP_001334545 NP_001334546 NP_695020 Location (UCSC) Chr 17: 81.9 – 81.9 Mb Chr 11: 120.5 – 120.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. It is expressed throughout the central nervous system with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.

See also

• Neuropeptide W

References

1. ^ GRCh38: Ensembl release 89: ENSG00000183979 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000044034 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Singh G, Davenport AP (Aug 2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". British Journal of Pharmacology. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
6. Hondo M, Ishii M, Sakurai T (2008). "The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion". Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation. Vol. 46. pp. 239–56. doi:10.1007/400_2007_056. ISBN 978-3-540-78350-3. PMID 18204824.

External links

• Uniprot: Neuropeptide B precursor

• Biology

• Genes on human chromosome 17
• G proteins
• Neuropeptides