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OR4F5
Identifiers
Aliases	OR4F5, olfactory receptor family 4 subfamily F member 5
External IDs	MGI: 3031123; HomoloGene: 128250; GeneCards: OR4F5; OMA:OR4F5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.33 Start 65,419 bp End 71,585 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E3 Start 111,311,164 bp End 111,314,960 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle Top expressed in embryo More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79501 258399 Ensembl ENSG00000186092 ENSMUSG00000061195 UniProt Q8NH21 Q8VF49 RefSeq (mRNA) NM_001005484 NM_146404 RefSeq (protein) NP_001005484 NP_666516 Location (UCSC) Chr 1: 0.07 – 0.07 Mb Chr 2: 111.31 – 111.31 Mb PubMed search
Wikidata
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Olfactory receptor family 4 subfamily F member 5 is a protein that in humans is encoded by the OR4F5 gene.

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Trivia

OR4F5 is the first protein coding gene on human chromosome 1.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000186092 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000061195 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Olfactory receptor family 4 subfamily F member 5".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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