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OS9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AIH
Identifiers
Aliases	OS9, ERLEC2, OS-9, endoplasmic reticulum lectin, OS9 endoplasmic reticulum lectin
External IDs	OMIM: 609677; MGI: 1924301; HomoloGene: 31409; GeneCards: OS9; OMA:OS9 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.3-q14.1 Start 57,693,955 bp End 57,721,557 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 D3 Start 126,931,519 bp End 126,957,000 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tendon of biceps brachii stromal cell of endometrium monocyte granulocyte body of pancreas islet of Langerhans minor salivary glands right lobe of thyroid gland mucosa of ileum Top expressed in lacrimal gland neural layer of retina submandibular gland granulocyte right kidney lip dentate gyrus of hippocampal formation granule cell parotid gland superior frontal gyrus molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding protein binding protease binding Cellular component Hrd1p ubiquitin ligase complex endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment endoplasmic reticulum Biological process protein targeting protein retention in ER lumen negative regulation of retrograde protein transport, ER to cytosol protein ubiquitination ubiquitin-dependent ERAD pathway response to endoplasmic reticulum stress endoplasmic reticulum mannose trimming transmembrane transport ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10956 216440 Ensembl ENSG00000135506 ENSMUSG00000040462 UniProt Q13438 Q8K2C7 RefSeq (mRNA) NM_001017956 NM_001017957 NM_001017958 NM_001261420 NM_001261421 NM_001261422 NM_001261423 NM_006812 NM_001171026 NM_177614 RefSeq (protein) NP_001017956 NP_001017957 NP_001017958 NP_001248349 NP_001248350 NP_001248351 NP_001248352 NP_006803 NP_001164497 NP_808282 Location (UCSC) Chr 12: 57.69 – 57.72 Mb Chr 10: 126.93 – 126.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Protein OS-9 is a protein that in humans is encoded by the OS9 gene.

Function

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000135506 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000040462 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Su YA, Hutter CM, Trent JM, Meltzer PS (Apr 1996). "Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas". Molecular Carcinogenesis. 15 (4): 270–5. doi:10.1002/(SICI)1098-2744(199604)15:4<270::AID-MC4>3.0.CO;2-K. PMID 8634085. S2CID 23490951.
6. Kimura Y, Nakazawa M, Tsuchiya N, Asakawa S, Shimizu N, Yamada M (Dec 1997). "Genomic organization of the OS-9 gene amplified in human sarcomas". Journal of Biochemistry. 122 (6): 1190–5. doi:10.1093/oxfordjournals.jbchem.a021880. PMID 9498564.
7. Hosokawa N, Kamiya Y, Kamiya D, Kato K, Nagata K (Jun 2009). "Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans". The Journal of Biological Chemistry. 284 (25): 17061–8. doi:10.1074/jbc.M809725200. PMC 2719344. PMID 19346256.
8. Christianson JC, Shaler TA, Tyler RE, Kopito RR (Mar 2008). "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD". Nature Cell Biology. 10 (3): 272–82. doi:10.1038/ncb1689. PMC 2757077. PMID 18264092.
9. ^ "Entrez Gene: OS9 amplified in osteosarcoma".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL (Feb 2005). "OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha". Molecular Cell. 17 (4): 503–12. doi:10.1016/j.molcel.2005.01.011. PMID 15721254.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Vigneron N, Ooms A, Morel S, Degiovanni G, Van Den Eynde BJ (Jul 2002). "Identification of a new peptide recognized by autologous cytolytic T lymphocytes on a human melanoma". Cancer Immunity. 2: 9. PMID 12747754.
• Litovchick L, Friedmann E, Shaltiel S (Sep 2002). "A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta". The Journal of Biological Chemistry. 277 (37): 34413–23. doi:10.1074/jbc.M203986200. PMID 12093806.
• Friedmann E, Salzberg Y, Weinberger A, Shaltiel S, Gerst JE (Sep 2002). "YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins". The Journal of Biological Chemistry. 277 (38): 35274–81. doi:10.1074/jbc.M201044200. PMID 12077121.
• Nakayama T, Yaoi T, Kuwajima G, Yoshie O, Sakata T (Jun 1999). "Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma". FEBS Letters. 453 (1–2): 77–80. doi:10.1016/S0014-5793(99)00700-0. PMID 10403379. S2CID 1290433.
• Kimura Y, Nakazawa M, Yamada M (May 1998). "Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines". Journal of Biochemistry. 123 (5): 876–82. doi:10.1093/oxfordjournals.jbchem.a022019. PMID 9562620.
• Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS (Jun 1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers". Genomics. 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850.

• Genes on human chromosome 12
• Proteins
• Genes