Odunsi is a surname. Notable people with the surname include:
- Akin Babalola Kamar Odunsi, Nigerian businessman and politician
- Anthony Odunsi (born 1992), American-born Nigerian basketball player
- Bowofoluwa Olufisayo Odunsi (born 1996), Nigerian singer-songrwriter professionally known as Odunsi the Engine
- Kunle Odunsi, American gynecologic oncologist
- Leke Odunsi (born 1980), English association football player
- Tomi Odunsi (born 1987), Nigerian television actress, singer, and songwriter
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