Ordzhonikidze or Orjonikidze (Georgian: ორჯონიკიძე) is a Georgian surname which may refer to:
Ordzhonikidze
- Grigoriy Ordzhonikidze (better known as Sergo Ordzhonikidze) (1886–1937), Georgian Bolshevik and Soviet political leader
- Sergei Ordzhonikidze, Russian diplomat
- Lika Ordzhonikidze, Georgian model
Orjonikidze
- Mindora Orjonikidze (1879—1967), Georgian politician
- Iza Orjonikidze, Georgian poet and politician
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