Ornipressin - Misplaced Pages

Ornipressin
Names

IUPAC name (2S)-N-- 1-oxopentan-2-yl]-1- -6,9,12,15,18-pentaoxo-13-(phenylmethyl)1,2-dithia-5,8,11,14,17- pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
Identifiers
CAS Number	3397-23-7
3D model (JSmol)	Interactive image
ChemSpider	16736525
ECHA InfoCard	100.020.231
MeSH	Ornipressin
PubChem CID	14257660
UNII	1KTH6N080W
CompTox Dashboard (EPA)	DTXSID101021593
InChI InChI=1S/C45H63N13O12S2/c46-16-4-8-28(39(64)51-21-37(50)62)53-44(69)34-9-5-17-58(34)45(70)33-23-72-71-22-27(47)38(63)54-30(19-25-10-12-26(59)13-11-25)42(67)55-31(18-24-6-2-1-3-7-24)41(66)52-29(14-15-35(48)60)40(65)56-32(20-36(49)61)43(68)57-33/h1-3,6-7,10-13,27-34,59H,4-5,8-9,14-23,46-47H2,(H2,48,60)(H2,49,61)(H2,50,62)(H,51,64)(H,52,66)(H,53,69)(H,54,63)(H,55,67)(H,56,65)(H,57,68)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1Key: MUNMIGOEDGHVLE-LGYYRGKSSA-N InChI=1/C45H63N13O12S2/c46-16-4-8-28(39(64)51-21-37(50)62)53-44(69)34-9-5-17-58(34)45(70)33-23-72-71-22-27(47)38(63)54-30(19-25-10-12-26(59)13-11-25)42(67)55-31(18-24-6-2-1-3-7-24)41(66)52-29(14-15-35(48)60)40(65)56-32(20-36(49)61)43(68)57-33/h1-3,6-7,10-13,27-34,59H,4-5,8-9,14-23,46-47H2,(H2,48,60)(H2,49,61)(H2,50,62)(H,51,64)(H,52,66)(H,53,69)(H,54,63)(H,55,67)(H,56,65)(H,57,68)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1Key: MUNMIGOEDGHVLE-LGYYRGKSBZ
SMILES NC(=O)CNC(=O)(CCCN)NC(=O)1CCCN1C(=O)4NC(=O)(NC(=O)(CCC(N)=O)NC(=O)(Cc2ccccc2)NC(=O)(Cc3ccc(O)cc3)NC(=O)(N)CSSC4)CC(N)=O
Properties
Chemical formula	C₄₅H₆₃N₁₃O₁₂S₂
Molar mass	1042.19 g/mol
Pharmacology
ATC code	H01BA05 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Y verify (what is ?) Infobox references

Chemical compound

Ornipressin is a vasoconstrictor, haemostatic and renal agent.

References

H. Fruhstofer, M.D., M. Heisler, M.D. (1994). "Dose-response relation of ornipressin with regard to vasoconstriction in human skin". Br. J. Anaesth. 73 (2): 220–224. doi:10.1093/bja/73.2.220. PMID 7917739.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Marc De Kock, MD, Pierre-Francois Laterre, MD, Patricia Andruetto, MD, Lionel Vanderessen, MD, Sylvie Dekrom, MD, Bernard Vanderick, MD and Patricia Lavand’homme, MD (June 2000). "Ornipressin (Por 8): An Efficient Alternative to Counteract Hypotension During Combined General/Epidural Anesthesia". Anesthesia & Analgesia. 90 (6): 1301–1307. doi:10.1097/00000539-200006000-00008. PMID 10825311. S2CID 44936158.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Oxytocin and vasopressin receptor modulators

Oxytocin

Agonists: Peptide: Aspartocin
Carbetocin
Cargutocin
Demoxytocin
Lipo-oxytocin-1
Merotocin
Nacartocin
Oxytocin
PF-06478939
PF-06655075 (PF1)
TGOT
Vasotocin (argiprestocin); Non-peptide: CA7
LIT-001
TC OT 39
WAY-267464
WJ0679

Vasopressin

V_1A	Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan Conivaptan FR-218944 JNJ-17079166 JNJ-17308616 LIT-001 LY-307174 PF-184563 Relcovaptan RG7713 SRX246 SRX251 TC OT 39 WAY-267464 YM-218 YM-471 YM-35471
V_1B	Agonists: Desmopressin Felypressin Lypressin Ornipressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: ABT-436 ABT-558 Brezivaptan Nelivaptan ORG-52186 (SCH-740935) TASP-0233278 TASP-0390325 Ligands: TASP-699
V₂	Agonists: Desmopressin Felypressin LIT-001 Lypressin Ornipressin TC OT 39 Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Conivaptan JNJ-17079166 Lixivaptan Mozavaptan RWJ-351647 Satavaptan Tolvaptan YM-471 YM-35471
Unsorted	Antagonists: Balovaptan Ribuvaptan RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate)

Others

Carrier proteins: Neurophysin (I, II)

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