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Otu deubiquitinase 5

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Protein-coding gene in the species Homo sapiens
OTUD5
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3PFY, 3TMO, 3TMP

Identifiers
AliasesOTUD5, DUBA, OTU deubiquitinase 5, MCAND
External IDsOMIM: 300713; MGI: 1859615; HomoloGene: 136483; GeneCards: OTUD5; OMA:OTUD5 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)
X chromosome (human)Genomic location for OTUD5Genomic location for OTUD5
BandXp11.23Start48,922,024 bp
End48,958,386 bp
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)
X chromosome (mouse)Genomic location for OTUD5Genomic location for OTUD5
BandX A1.1|X 3.54 cMStart7,707,603 bp
End7,742,865 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of arm

  • cardiac muscle tissue of right atrium

  • granulocyte

  • nasal epithelium

  • right hemisphere of cerebellum

  • prefrontal cortex

  • left ovary

  • right ovary

  • spleen

  • right frontal lobe
Top expressed in
  • granulocyte

  • Ileal epithelium

  • blood

  • neural layer of retina

  • zygote

  • thymus

  • dentate gyrus of hippocampal formation granule cell

  • tibiofemoral joint

  • superior frontal gyrus

  • ventricular zone
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55593

54644

Ensembl

ENSG00000068308

ENSMUSG00000031154

UniProt

Q96G74

Q3U2S4

RefSeq (mRNA)

NM_001136157
NM_001136158
NM_001136159
NM_017602

NM_001290536
NM_001290537
NM_138604

RefSeq (protein)

NP_001129629
NP_001129630
NP_001129631
NP_060072

NP_001277465
NP_001277466
NP_613070

Location (UCSC)Chr X: 48.92 – 48.96 MbChr X: 7.71 – 7.74 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

OTU deubiquitinase 5 is a protein that in humans is encoded by the OTUD5 gene.

Function

This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000068308 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000031154 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: OTU deubiquitinase 5". Retrieved 2017-03-25.

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: Q96G74 (Human OTU domain-containing protein 5) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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