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PACSIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HAH, 3HAI, 3Q84, 3QNI
Identifiers
Aliases	PACSIN1, SDPI, protein kinase C and casein kinase substrate in neurons 1
External IDs	OMIM: 606512; MGI: 1345181; HomoloGene: 22674; GeneCards: PACSIN1; OMA:PACSIN1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.31 Start 34,466,061 bp End 34,535,229 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A3.3 Start 27,874,483 bp End 27,930,456 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe superior frontal gyrus postcentral gyrus entorhinal cortex middle temporal gyrus primary visual cortex dorsolateral prefrontal cortex anterior cingulate cortex right hemisphere of cerebellum prefrontal cortex Top expressed in pontine nuclei piriform cortex superior frontal gyrus primary visual cortex subiculum dorsal tegmental nucleus cerebellar cortex neural layer of retina primary motor cortex prefrontal cortex More reference expression data BioGPS n/a
Gene ontology Molecular function cytoskeletal protein binding protein binding phospholipid binding lipid binding identical protein binding Cellular component cytoplasm axon terminus cytosol endosome cell projection membrane myelin sheath plasma membrane synapse ruffle membrane cell junction perinuclear region of cytoplasm neuron projection cytoplasmic vesicle membrane cytoplasmic vesicle COPI-coated vesicle cytoskeleton photoreceptor ribbon synapse presynaptic endocytic zone Biological process regulation of endocytosis negative regulation of endocytosis protein localization to membrane neuron projection morphogenesis endocytosis actin filament organization neuron development positive regulation of dendrite development plasma membrane tubulation synaptic vesicle endocytosis protein localization to plasma membrane cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29993 23969 Ensembl ENSG00000124507 ENSMUSG00000040276 UniProt Q9BY11 Q61644 RefSeq (mRNA) NM_001199583 NM_020804 NM_001286743 NM_001286744 NM_011861 NM_178365 RefSeq (protein) NP_001186512 NP_065855 NP_001273672 NP_001273673 NP_035991 NP_848142 Location (UCSC) Chr 6: 34.47 – 34.54 Mb Chr 17: 27.87 – 27.93 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Protein kinase C and casein kinase substrate in neurons protein 1 also known as syndapin I is an enzyme that in humans is encoded by the PACSIN1 gene.

Interactions

PACSIN1 has been shown to interact with GTPases of the Dynamin family (Dynamin 1, 2 and 3). Based on this interaction, its localization and functional role the protein was named syndapin I (synaptic dynamin-associated protein I).

A variety of interactions have been published:

• DNM1
• Huntingtin
• PACSIN2
• PACSIN3

References

1. ^ GRCh38: Ensembl release 89: ENSG00000124507 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000040276 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "PACSIN1 protein kinase C and casein kinase substrate in neurons 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-08-04.
6. "Pacsin1 protein kinase C and casein kinase substrate in neurons 1 [Mus musculus (house mouse)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-08-04.
7. Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M (Jan 2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene. 262 (1–2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.
8. Qualmann B, Roos J, DiGregorio PJ, Kelly RB (February 1999). Pfeffer SR (ed.). "Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein". Molecular Biology of the Cell. 10 (2): 501–513. doi:10.1091/mbc.10.2.501. PMC 25183. PMID 9950691.
9. Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, et al. (Sep 2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". The Journal of Biological Chemistry. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
10. ^ Modregger J, Ritter B, Witter B, Paulsson M, Plomann M (Dec 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". Journal of Cell Science. 113 (24): 4511–21. doi:10.1242/jcs.113.24.4511. PMID 11082044.
11. Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M (Oct 2002). "PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains". Human Molecular Genetics. 11 (21): 2547–58. doi:10.1093/hmg/11.21.2547. PMID 12354780.
12. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Zucconi A, Dente L, Santonico E, Castagnoli L, Cesareni G (Apr 2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1". Journal of Molecular Biology. 307 (5): 1329–39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
• Wasiak S, Quinn CC, Ritter B, de Heuvel E, Baranes D, Plomann M, et al. (Jul 2001). "The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton". The Journal of Biological Chemistry. 276 (28): 26622–8. doi:10.1074/jbc.M100591200. PMID 11352907.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1)

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