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PAR1 (gene)

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PWAR1

Identifiers

PWAR1, D15S227E, PAR-1, PAR1, Prader Willi/Angelman region RNA 1

External IDs

OMIM: 600161; GeneCards: PWAR1; OMA:PWAR1 - orthologs

Gene location (Human)

Chr.	Chromosome 15 (human)

Band	15q11.2	Start	25,135,642 bp
Band	15q11.2	End	25,138,055 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

testicle

skeletal muscle tissue

muscle of leg

ganglionic eminence

primary visual cortex

muscle of thigh

right lobe of thyroid gland

prefrontal cortex

superior frontal gyrus

left lobe of thyroid gland

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More reference expression data

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Species

Human

Mouse


145624


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ENSG00000279050


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n a


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RefSeq (mRNA)


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RefSeq (protein)


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Location (UCSC)

Chr 15: 25.14 – 25.14 Mb

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PubMed search

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View/Edit Human

Prader-Willi/Angelman region-1, also known as PWAR1, is an exon of the lncRNA Small nucleolar RNA host gene 14 (SNHG14).

References

^ GRCh38: Ensembl release 89: ENSG00000279050 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: PAR1 Prader-Willi/Angelman region-1".

Further reading

Sutcliffe JS, Nakao M, Christian S, et al. (1995). "Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region". Nat. Genet. 8 (1): 52–8. doi:10.1038/ng0994-52. PMID 7987392. S2CID 31504627.
Schulze A, Hansen C, Skakkebaek NE, et al. (1996). "Exclusion of SNRPN as a major determinant of Prader-Willi syndrome by a translocation breakpoint". Nat. Genet. 12 (4): 452–4. doi:10.1038/ng0496-452. PMID 8630505. S2CID 22259236.
Christian SL, Bhatt NK, Martin SA, et al. (1998). "Integrated YAC contig map of the Prader-Willi/Angelman region on chromosome 15q11-q13 with average STS spacing of 35 kb". Genome Res. 8 (2): 146–57. doi:10.1101/gr.8.2.146. PMC 310691. PMID 9477342.
Wirth J, Back E, Hüttenhofer A, et al. (2001). "A translocation breakpoint cluster disrupts the newly defined 3' end of the SNURF-SNRPN transcription unit on chromosome 15". Hum. Mol. Genet. 10 (3): 201–10. doi:10.1093/hmg/10.3.201. PMID 11159938.
Dorsam RT, Tuluc M, Kunapuli SP (2005). "Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets". J. Thromb. Haemost. 2 (5): 804–12. doi:10.1111/j.1538-7836.2004.00692.x. PMID 15099288. S2CID 20124469.
Nakayama T, Hirano K, Hirano M, et al. (2004). "Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells". Biochem. Pharmacol. 68 (1): 23–32. doi:10.1016/j.bcp.2004.03.005. PMID 15183114.
Shi X, Gangadharan B, Brass LF, et al. (2005). "Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis". Mol. Cancer Res. 2 (7): 395–402. doi:10.1158/1541-7786.395.2.7. PMID 15280447. S2CID 31329993.
Heider I, Schulze B, Oswald E, et al. (2005). "PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism". Oncol. Res. 14 (10): 475–82. doi:10.3727/0965040042380496. PMID 15559761.
Tantivejkul K, Loberg RD, Mawocha SC, et al. (2005). "PAR1-mediated NFkappaB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism" (PDF). J. Cell. Biochem. 96 (3): 641–52. doi:10.1002/jcb.20533. hdl:2027.42/48764. PMID 16052512. S2CID 34707839.

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