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PCGEM1

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Not to be confused with PC GEM.
PCGEM1
Identifiers
AliasesPCGEM1, LINC00071, NCRNA00071, PCAT9, prostate-specific transcript (non-protein coding), prostate-specific transcript, PCGEM1 prostate-specific transcript
External IDsOMIM: 605443; GeneCards: PCGEM1; OMA:PCGEM1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)
Chromosome 2 (human)Genomic location for PCGEM1Genomic location for PCGEM1
Band2q32.3Start192,749,845 bp
End192,776,899 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • prostate

  • epithelium of colon

  • prefrontal cortex

  • monocyte

  • reproductive organ

  • Amygdala

  • islet of Langerhans

  • olfactory zone of nasal mucosa

  • primary visual cortex
    n/a
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

64002

n/a

Ensembl

ENSG00000227418

n/a

UniProt

n
a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 2: 192.75 – 192.78 Mbn/a
PubMed searchn/a
Wikidata
View/Edit Human
Prostate-specific transcript 1
Predicted secondary structure and sequence conservation of PCGEM1
Identifiers
SymbolPCGEM1
RfamRF01981
Other data
RNA typeGene;
Domain(s)Eukaryota;
GOGO:0042981
SOSO:0001463
PDB structuresPDBe

Prostate-specific transcript 1 (non-protein coding), also known as PCGEM1, is a long non-coding RNA gene. In humans, it is located on chromosome 2q32. It is over-expressed in prostate cancer. In a study of prostate tumours from 88 men, levels of PCGEM1 were found to be higher in prostate cancer cells in African-American men than in Caucasian-American men. The mortality rate of prostate cancer is highest in African-American men.

PCGEM1 inhibits doxorubicin-induced apoptosis of cells, via delayed induction of p53 and p21.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000227418 – Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Srikantan V, Zou Z, Petrovics G, et al. (October 2000). "PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer". Proc. Natl. Acad. Sci. U.S.A. 97 (22): 12216–12221. Bibcode:2000PNAS...9712216S. doi:10.1073/pnas.97.22.12216. PMC 17321. PMID 11050243.
  4. Bialkowska-Hobrzanska H, Driman DK, Fletcher R, Harry V, Razvi H (February 2006). "Expression of human telomerase reverse transcriptase, Survivin, DD3 and PCGEM1 messenger RNA in archival prostate carcinoma tissue". Can J Urol. 13 (1): 2967–2974. PMID 16515751.
  5. Petrovics G, Zhang W, Makarem M, et al. (January 2004). "Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients". Oncogene. 23 (2): 605–611. doi:10.1038/sj.onc.1207069. PMID 14724589.
  6. Fu X, Ravindranath L, Tran N, Petrovics G, Srivastava S (March 2006). "Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1". DNA Cell Biol. 25 (3): 135–141. doi:10.1089/dna.2006.25.135. PMID 16569192.

Further reading

External links

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