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PHACTR3

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Protein-coding gene in the species Homo sapiens
PHACTR3
Identifiers
AliasesPHACTR3, C20orf101, H17739, PPP1R123, SCAPIN1, SCAPININ, phosphatase and actin regulator 3
External IDsOMIM: 608725; MGI: 1921439; HomoloGene: 14482; GeneCards: PHACTR3; OMA:PHACTR3 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)
Chromosome 20 (human)Genomic location for PHACTR3Genomic location for PHACTR3
Band20q13.32-q13.33Start59,577,509 bp
End59,847,711 bp
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)
Chromosome 2 (mouse)Genomic location for PHACTR3Genomic location for PHACTR3
Band2|2 H4Start177,760,768 bp
End177,980,285 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Amygdala

  • internal globus pallidus

  • C1 segment

  • substantia nigra

  • corpus callosum

  • cingulate gyrus

  • anterior cingulate cortex

  • right frontal lobe

  • Brodmann area 9

  • hippocampus proper
Top expressed in
  • piriform cortex

  • olfactory tubercle

  • superior frontal gyrus

  • cingulate gyrus

  • globus pallidus

  • superior cervical ganglion

  • Temporal Lobe

  • visual cortex

  • primary motor cortex

  • hippocampus proper
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

116154

74189

Ensembl

ENSG00000087495

ENSMUSG00000027525

UniProt

Q96KR7

Q8BYK5

RefSeq (mRNA)
NM_001199505
NM_001199506
NM_001281507
NM_080672
NM_183244

NM_183246

NM_001007154
NM_001177789
NM_001177790
NM_001177791
NM_028806

RefSeq (protein)
NP_001186434
NP_001186435
NP_001268436
NP_542403
NP_899067

NP_899069

NP_001007155
NP_001171260
NP_001171261
NP_001171262
NP_083082

Location (UCSC)Chr 20: 59.58 – 59.85 MbChr 2: 177.76 – 177.98 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene.

Function

The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.

Interactions

PHACTR3 has been shown to interact with PPP1CA.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000087495 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000027525 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (May 2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins". Proc Natl Acad Sci U S A. 101 (18): 7187–92. Bibcode:2004PNAS..101.7187A. doi:10.1073/pnas.0401673101. PMC 406487. PMID 15107502.
  6. ^ "Entrez Gene: PHACTR3 phosphatase and actin regulator 3".
  7. Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (Nov 2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532.

Further reading


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