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PPP1R12C
Identifiers
Aliases	PPP1R12C, LENG3, MBS85, p84, p85, protein phosphatase 1 regulatory subunit 12C, AAVS1
External IDs	OMIM: 613245; MGI: 1924258; HomoloGene: 75071; GeneCards: PPP1R12C; OMA:PPP1R12C - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.42 Start 55,090,914 bp End 55,117,637 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A1 Start 4,484,519 bp End 4,504,679 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa muscle layer of sigmoid colon body of uterus apex of heart left testis canal of the cervix right testis left uterine tube popliteal artery tibial arteries Top expressed in granulocyte neural layer of retina superior frontal gyrus interventricular septum lip primary visual cortex dentate gyrus of hippocampal formation granule cell ventricular zone cerebellar cortex thymus More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase binding protein binding phosphatase regulator activity enzyme inhibitor activity Cellular component cytoplasm cytoskeleton Biological process signal transduction regulation of catalytic activity negative regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54776 232807 Ensembl ENSG00000125503 ENSMUSG00000019254 UniProt Q9BZL4 Q3UMT1 RefSeq (mRNA) NM_001271618 NM_017607 NM_029834 RefSeq (protein) NP_001258547 NP_060077 NP_084110 Location (UCSC) Chr 19: 55.09 – 55.12 Mb Chr 7: 4.48 – 4.5 Mb PubMed search
Wikidata
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Protein phosphatase 1 regulatory subunit 12C is a protein that in humans is encoded by the PPP1R12C gene.

Function

The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000125503 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000019254 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Protein phosphatase 1 regulatory subunit 12C". Retrieved 2016-11-14.

Further reading

• Surks HK, Richards CT, Mendelsohn ME (2003). "Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA". J. Biol. Chem. 278 (51): 51484–93. doi:10.1074/jbc.M305622200. PMID 14506264.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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