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PPP1R2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2O8A, 2O8G
Identifiers
Aliases	PPP1R2, IPP-2, IPP2, protein phosphatase 1 regulatory inhibitor subunit 2, PPP1R2A
External IDs	OMIM: 601792; MGI: 1914099; HomoloGene: 4546; GeneCards: PPP1R2; OMA:PPP1R2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q29 Start 195,514,428 bp End 195,543,386 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 B2|16 21.41 cM Start 31,070,355 bp End 31,094,095 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis muscle of thigh sperm jejunal mucosa gastrocnemius muscle bone marrow vastus lateralis muscle bone marrow cells Top expressed in granulocyte superior frontal gyrus tail of embryo lip muscle of thigh spermatocyte lumbar spinal ganglion genital tubercle ventricular zone aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine phosphatase inhibitor activity protein phosphatase inhibitor activity protein binding Cellular component protein phosphatase type 1 complex Biological process glycogen metabolic process regulation of phosphoprotein phosphatase activity regulation of signal transduction generation of precursor metabolites and energy carbohydrate metabolic process negative regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5504 66849 Ensembl ENSG00000184203 ENSMUSG00000047714 UniProt P41236 Q9DCL8 RefSeq (mRNA) NM_001291504 NM_001291505 NM_006241 NM_001316325 NM_025800 RefSeq (protein) NP_001278433 NP_001278434 NP_001303254 NP_006232 NP_080076 Location (UCSC) Chr 3: 195.51 – 195.54 Mb Chr 16: 31.07 – 31.09 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Protein phosphatase inhibitor 2 is an enzyme that in humans is encoded by the PPP1R2 gene.

Interactions

PPP1R2 has been shown to interact with LMTK2 and PPP1R9B.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000184203 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000047714 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Permana PA, Mott DM (April 1997). "Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians". Genomics. 41 (1): 110–4. doi:10.1006/geno.1997.4649. PMID 9126490.
6. Helps NR, Street AJ, Elledge SJ, Cohen PT (February 1994). "Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli". FEBS Letters. 340 (1–2): 93–8. doi:10.1016/0014-5793(94)80179-7. PMID 8119416. S2CID 10674654.
7. "Entrez Gene: PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2".
8. Wang H, Brautigan DL (December 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". The Journal of Biological Chemistry. 277 (51): 49605–12. doi:10.1074/jbc.M209335200. PMID 12393858.
9. Terry-Lorenzo RT, Elliot E, Weiser DC, Prickett TD, Brautigan DL, Shenolikar S (November 2002). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". The Journal of Biological Chemistry. 277 (48): 46535–43. doi:10.1074/jbc.M206960200. PMID 12270929.

Further reading

• Sanséau P, Jackson A, Alderton RP, Beck S, Senger G, Sheer D, et al. (August 1994). "Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences". Mammalian Genome. 5 (8): 490–6. doi:10.1007/BF00369318. PMID 7949733. S2CID 11381670.
• Park IK, Roach P, Bondor J, Fox SP, DePaoli-Roach AA (January 1994). "Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2". The Journal of Biological Chemistry. 269 (2): 944–54. doi:10.1016/S0021-9258(17)42203-4. PMID 8288648.
• Kakinoki Y, Somers J, Brautigan DL (December 1997). "Multisite phosphorylation and the nuclear localization of phosphatase inhibitor 2-green fluorescent protein fusion protein during S phase of the cell growth cycle". The Journal of Biological Chemistry. 272 (51): 32308–14. doi:10.1074/jbc.272.51.32308. PMID 9405437.
• Yang J, Hurley TD, DePaoli-Roach AA (July 2000). "Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif". The Journal of Biological Chemistry. 275 (30): 22635–44. doi:10.1074/jbc.M003082200. PMID 10807923.
• Agarwal-Mawal A, Paudel HK (June 2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2". The Journal of Biological Chemistry. 276 (26): 23712–8. doi:10.1074/jbc.M010002200. PMID 11320080.
• Eto M, Elliott E, Prickett TD, Brautigan DL (November 2002). "Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation". The Journal of Biological Chemistry. 277 (46): 44013–20. doi:10.1074/jbc.M208035200. PMID 12221103.
• Terry-Lorenzo RT, Elliot E, Weiser DC, Prickett TD, Brautigan DL, Shenolikar S (November 2002). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". The Journal of Biological Chemistry. 277 (48): 46535–43. doi:10.1074/jbc.M206960200. PMID 12270929.
• Wang H, Brautigan DL (December 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". The Journal of Biological Chemistry. 277 (51): 49605–12. doi:10.1074/jbc.M209335200. PMID 12393858.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Leach C, Shenolikar S, Brautigan DL (July 2003). "Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis". The Journal of Biological Chemistry. 278 (28): 26015–20. doi:10.1074/jbc.M300782200. PMID 12697755.
• Sakashita G, Shima H, Komatsu M, Urano T, Kikuchi A, Kikuchi K (February 2003). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells". Journal of Biochemistry. 133 (2): 165–71. doi:10.1093/jb/mvg020. PMID 12761178.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Yamada M, Ikeda Y, Yano M, Yoshimura K, Nishino S, Aoyama H, et al. (June 2006). "Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy". FASEB Journal. 20 (8): 1197–9. doi:10.1096/fj.05-5299fje. PMID 16627625. S2CID 911020.
• King TD, Gandy JC, Bijur GN (November 2006). "The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels". Experimental Cell Research. 312 (18): 3693–700. doi:10.1016/j.yexcr.2006.08.010. PMC 1885546. PMID 16987514.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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