Paulose II may refer to:
- Athanasius Paulose II (1915–1991), First Metropolitan of Evangelistic Association of the East consecrated as Metropolitan in 1973
- Baselios Paulose II, Catholicos of the Jacobite Syrian Christian Church in 1975–2002
- Paulose II (Indian Orthodox Church), Catholicos of the East and Supreme Head of the Indian Orthodox Church since 2010 until his death in 2021.
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