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Peptide-methionine (S)-S-oxide reductase (EC 1.8.4.11, MsrA, methionine sulphoxide reductase A, methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase A, peptide methionine sulfoxide reductase, formerly protein-methionine-S-oxide reductase) is an enzyme with systematic name peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase (L-methionine (S)-S-oxide-forming). This enzyme catalyses the following chemical reaction

(1) peptide-L-methionine + thioredoxin disulfide + H₂O ${\displaystyle \rightleftharpoons }$ peptide-L-methionine (S)-S-oxide + thioredoxin

(2) L-methionine + thioredoxin disulfide + H₂O ${\displaystyle \rightleftharpoons }$ L-methionine (S)-S-oxide + thioredoxin

The reaction occurs in the reverse direction.

References

1. Moskovitz J, Singh VK, Requena J, Wilkinson BJ, Jayaswal RK, Stadtman ER (January 2002). "Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity". Biochemical and Biophysical Research Communications. 290 (1): 62–5. doi:10.1006/bbrc.2001.6171. PMID 11779133.
2. Taylor AB, Benglis DM, Dhandayuthapani S, Hart PJ (July 2003). "Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine". Journal of Bacteriology. 185 (14): 4119–26. doi:10.1128/JB.185.14.4119-4126.2003. PMC 164888. PMID 12837786.
3. Singh VK, Moskovitz J (October 2003). "Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress". Microbiology. 149 (Pt 10): 2739–47. doi:10.1099/mic.0.26442-0. PMID 14523107.
4. Boschi-Muller S, Olry A, Antoine M, Branlant G (January 2005). "The enzymology and biochemistry of methionine sulfoxide reductases". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1703 (2): 231–8. doi:10.1016/j.bbapap.2004.09.016. PMID 15680231.
5. Ezraty B, Aussel L, Barras F (January 2005). "Methionine sulfoxide reductases in prokaryotes". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1703 (2): 221–9. doi:10.1016/j.bbapap.2004.08.017. PMID 15680230.
6. Weissbach H, Resnick L, Brot N (January 2005). "Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1703 (2): 203–12. doi:10.1016/j.bbapap.2004.10.004. PMID 15680228.
7. Kauffmann B, Aubry A, Favier F (January 2005). "The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1703 (2): 249–60. doi:10.1016/j.bbapap.2004.09.008. PMID 15680233.
8. Vougier S, Mary J, Friguet B (July 2003). "Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells". The Biochemical Journal. 373 (Pt 2): 531–7. doi:10.1042/BJ20030443. PMC 1223498. PMID 12693988.
9. Olry A, Boschi-Muller S, Marraud M, Sanglier-Cianferani S, Van Dorsselear A, Branlant G (April 2002). "Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis". The Journal of Biological Chemistry. 277 (14): 12016–22. doi:10.1074/jbc.M112350200. PMID 11812798.
10. Brot N, Weissbach L, Werth J, Weissbach H (April 1981). "Enzymatic reduction of protein-bound methionine sulfoxide". Proceedings of the National Academy of Sciences of the United States of America. 78 (4): 2155–8. doi:10.1073/pnas.78.4.2155. PMC 319302. PMID 7017726.

External links

• Peptide-methionine+(S)-S-oxide+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 1.8.4