Phil O'Brien may refer to:
- Phil O'Brien, pen name of Irish dramaturge Philomena Muinzer
- Phil O'Brien, Australian writer, musician and filmmaker who made a film in Nhulunbuy, Northern Territory
- Phil O'Brien, past president of the New York Press Club, 1993–94
- Phil O'Brien, broadcaster on TVNZ and Radio New Zealand
- Phil O'Brien (athlete), competed in the 1983 IAAF World Cross Country Championships – Senior men's race
- Phil O'Brien (entrepreneur), former photographer, founder of EMPICS in 1985
- Phil O'Brien (footballer) (1930–2020), Australian rules football player
- Phil O'Brien (motorcyclist), Australian motorcyclist in the 1969 Grand Prix motorcycle racing season, 500cc race
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