Phil S. Baran - Misplaced Pages

American organic chemist

Phil S. Baran

Born	August 10, 1977 (1977-08-10) (age 47) Denville, NJ
Nationality	American
Alma mater	Lake Sumter Community College (AA, 1995) New York University (BS, 1997) Scripps Research Institute (PhD, 2001)
Scientific career
Fields	Chemistry
Institutions	Skaggs Institute for Chemical Biology

Phil S. Baran (born August 10, 1977) is a synthetic organic chemist and Professor in the Department of Chemistry at the Scripps Research Institute. His work is focused on synthesizing complex natural products, the development of new reaction methodologies within synthetic organic electrochemistry, and the development of new reagents. He holds several patents and has authored nearly 300 research articles.

Early life and education

Phil S. Baran was born in Denville, New Jersey, on August 10, 1977, and grew up in Coral Springs, Florida. He remembers being a poor student at high school, preferring to play role-playing games, write computer programs and build with Lego.

Encouraged by his chemistry teacher to experiment after school, Baran quickly channeled his creativity into crafting molecules. In 1995 he began a chemistry degree at New York University, and enthusiastically accepted Schuster’s offer to work in his lab, synthesizing compounds that linked C60 with porphyrins to make artificial photosynthetic systems. He received his BS in chemistry from New York University in 1997.

He went on to earn his PhD from The Scripps Research Institute in 2001, under the supervision of K. C. Nicolaou, an experience he recalls was 'like hardcore Navy Seal training' and where he co-authored 30 papers in less than four years.

He then pursued a postdoctoral fellowship in the laboratory of Nobel Laureate Elias James Corey at Harvard University who reflected on Baran's time in his lab, saying, "He had a phenomenal grasp of synthetic chemistry," and "felt that he could be a leader in his generation."

Independent academic career

Neon OPEN sign above Phil Baran's office door

Phil Baran began his independent career at the Scripps Research Institute in the summer of 2003, at only 26 years old, and received tenure just three years later. In the 20 years since then, he has supervised over 300 graduate students, post-doctoral scholars, visiting scholars and interns. He is currently the Dr. Richard A. Lerner Endowed Chair at Scripps Research

His work is focused on practicality and simplicity in the total synthesis of organic molecules, eschewing protecting groups, functional group manipulations, and non-essential redox manipulations. Several of his total syntheses are now being adopted for commercial production. His contributions in methodology center around practical C-H functionalization reactions and have had a remarkable impact based on actual drug candidates brought into the clinic using these methods and the sales of numerous reagents he has commercialized for use in the pharmaceutical industry. Additionally, since the mid 2010's, Baran's lab has focused on developing electrochemical methodologies for use in total synthesis and medicinal chemistry as it allows for more atom economical and environmentally-conscious protocols.

Phil Baran has given hundreds of talks all over the world and is the recipient of dozens of distinguished awards. Among many honors, he has notably earned the Amgen Young Investigator Award (2005), ACS Award in Pure Chemistry (2010), the MacArthur Fellowship (2013), the Mukaiyama Award (2014), the ACS Elias J. Corey Award (2016), the Danisco Science Excellence Medal Award (2022), and the Edison Patent Award (2023).

Industry career and collaborations

In addition to his numerous achievements in academia, Baran also holds many accolades in industry as a scientific entrepreneur, company co-founder, consultant and scientific advisor. He co-founded his first company Sirenas Marine Discovery in 2012 alongside Eduardo Esquenazi and Jake Beverage —a company that is dedicated to marine-inspired molecular discoveries and pre-clinical leads for cancer, HIV, and infectious diseases. In 2016, he joined forces with fellow Scripps colleagues, Benjamin F. Cravatt and Jin-Quan Yu to co-found Vividion Therapeutics with the goal of identifying small molecules that bind currently undrugged targets via a covalent-first chemoproteomics approach. Vividion was sold to Bayer in 2021 for $2 billion ($1.5 billion with an additional $500 million in milestone payments). In the same year, Baran founded Elsie Biotechnologies, an antisense oligonucleotide (ASO)-based company with the goal of discovering therapeutic agents that can achieve desirable medicinal effects not attainable with existing drugs by modulating gene expression of DNA or RNA. Elsie Biotechnologies was sold to GlaxoSmithKline (GSK) in 2024 for $50 million. Baran also co-founded and is on the scientific advisory team of Galileo Biosystems, a preclinical stage biopharmaceutical company focused on developing therapeutic agents for inflammatory and autoimmune diseases. He also serves on the scientific advisory board for seven additional companies (Eisai, Kemxtree, Quanta Therapeutics, Inc., Alkermes, Inc, Nutcracker Therapeutics, Inc., Hongene Biotech Corporation, and Sage Therapeutics) and has consulted for over twenty more, including presently at Bristol-Meyers-Squibb, Gilead, and BASF Corporation.

In 2014, Baran began a partnership with IKA, well-known laboratory equipment manufacturer, to bring to market a revolutionary piece of equipment that promised to standardize electrochemical protocols and make electrochemistry accessible to the average organic chemist. Three years after the partnership began, the ElectraSyn was debuted in a Steve Jobs-esque fashion at the American Chemical Society annual meeting, drawing a large crowd of eager chemists. In the seven years since, the ElectraSyn and subsequent ElectraSyn 2.0 have been widely adopted into the synthetic community and utilized towards hundreds of research articles and patents. The publicity surrounding Baran's (as well as Jin-Quan Yu's) partnership with IKA was highlighted with a memorable promotional video found here.

Strategies for synthesis

1. Ideality

In June 2010, Baran authored a paper describing the “Ideal Synthesis” in which he presents a simple and informative definition of “ideality” when comparing molecular syntheses. Building off of ideas discussed by James B. Hendrickson in 1975, “ideality” refers to the concept of making molecules in a way that minimizes concession steps (e.g. adding/removing protecting groups) and maximizes construction steps (i.e. C-C or C-heteroatom bond forming and strategic redox steps). Importantly, this conversation of synthetic ideality is limited to comparisons of syntheses of the same molecule.

Considerations for the ideal synthesis:

Minimize non-C-C or C-heteroatom bond forming reactions
Maximize the percentage of C−C bond-forming and strategic C−C bond-breaking events relative to the total number of steps
Choose disconnections that maximize convergency
Redox-Economical: the oxidation state of intermediates should fluctuate as little as possible during the synthesis
Maximize structural changes per step (using cascade or tandem reactions)
Protecting Group-free synthesis: reduce or eliminate protecting group concession steps
Invention-oriented discoveries: effort should be spent on the invention of new methodology to facilitate the aforementioned criteria and to uncover new aspects of chemical reactivity
Minimize known biosynthetic pathways (unless they support above considerations)

2. Two-Phase Synthesis

A unique approach to the synthesis of terpenes was put forth and executed in the context of numerous natural products that loosely mimics the way Nature crafts such molecules. By rapidly building up a carbon skeleton followed by oxygenation dramatically shorter routes are made possible as exemplified with the syntheses listed below:

14-Step Synthesis of (+)-Ingenolfrom (+)-3-Carene
C-H Oxidation of Ingenanes Enables Potent and Selective Protein Kinase C Isoform Activation
Development of a Concise Synthesis of (-)-Ingenol
Nineteen-step total synthesis of (+)-phorbol
Scalable Synthesis of (-)-Thapsigargin
Divergent synthesis of thapsigargin analogs
Two-Phase Synthesis of (−)-Taxuyunnanine D
Two-Phase Synthesis of Taxol
Short, Enantioselective Total Synthesis of Highly Oxidized Taxanes

3. Radical Retrosynthesis

Radical retrosynthesis adds to the toolbox of synthetic planning by additionally considering intuitive radical disconnections and cross-coupling molecular partners. As methods develop towards more 1e- thinking, this strategic and tactical approach to synthesis will continue to aid in the construction of interesting and valuable natural products and medicinally important compounds. Radical retrosynthesis maximizes convergency by making disconnections that are not wedded to traditional polar bond analysis. The most useful methods from a tactical standpoint in this regard use radical cross coupling. (See Radical Chemistry under Methods Toward Synthesis).

4. Practical & Scalable Syntheses

Implicit in aiming for the ideal synthesis is being able to access useful quantities of a molecule by simple, scalable routes.

Total syntheses

Dragocins A−C (2024)
Dynobactin A (2024)
(−)-Cyclopamine (2023)
(+)-KB343 (2023)
Portimine A and B (2023)
Kibdelomycin (2022)
Darobactin A (2022)
(+)-Calcipotriol (2022)
Tagetitoxin (2020)
(–)-Maximiscin (2020)
Taxol (2020)
Teleocidins B-1-B-4 (2019)
Herqulines B and C (2019)
Subglutinols A & B (2018)
Higginsianin A (2018)
Sesquicillin A (2018)
(–)-Thapsigargin (2017)
Arylomycin A-C16 (2017)
Ariaosamines (2016)
(–)-Maoecrystal V (2016)
Pallambins C and D (2016)
(+)-Phorbol (2016)
Verruculogen (2015)
Fumitremorgin A (2015)
Ouabagenin (2013, 2015)
(−)-Hapalindole U (2015)
(+)-Ambiguine H (2015)
Tomentogenin (2015)
Pergularin (2015)
Utendin (2015)
Dixiamycin B (2014)
(+)-Ingenol (2014)
(–)-Taxuyunnanine (2014)
Dictazole A (2014)
(−)-methyl atisenoate (2014)
(−)-isoatisine (2014)
(+)-Hongoquercin A (2013)
(+)-Hongoquercin A (2013)
Phellodonin (2013)
Sarcodonin (2013)
Pipercyclobutanamide A (2012)
(+)-Taxadienone (2011)
(+)-Psychotetramine (2011)
Piperarborenine B &D (2011)
(–)-Palau’amine (2010)
Dihydrojunenol (2010)
Vinigrol (2009)
Kapakahines B and F (2009)
(±)-Massadine (2008)
(±)-Psychotrimine (2008)
Cortistatin A (2008)
(–)-Axinellamine A and B (2008)
(±)-Chartelline C (2006)
(−)-Bursehernin (2006)
Haouamine A (2006)
Avrainvillamide (2005)
Stephacidin A & B (2005)
(S)-Ketorolac (2005)
(+)-hapalindole Q (2004)
(−)-12-epi-fischerindole U isothiocyanate (2004)
Sceptrin (2004)

Methods towards synthesis

C-H Functionalization

Radical-mediated C-H functionalization (alcohols to 1,3-diols) (2008)
Chemoselective N-tert-Prenylation of Indoles by C–H Functionalization (2009)
C-H trifluoromethylation of heterocylces (2011)
Cyclobutane C–H arylation (2011)
C–H amination of unactivated sp carbons (2012)
C–H functionalization of heterocycles via Zn sulphinate salts (2012)
C–H Imidation of (Hetero)Arenes (2013)
C–H functionalization by sulfinate-derived radicals (2013)
C–H Trifluoromethylcyclopropanation via sulfinate reagents(2013)
Ligand-Controlled C-H Borylation (2015)
Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids (2019)
Methylation of heteroarenes (2014)
Bioconjugation by Native Chemical Tagging of C–H Bonds
Direct Synthesis of Fluorinated Heteroarylether Bioisosteres (2013)

Olefin Functionalization

Direct coupling of unactivated olefins to electron-deficient olefins (2013)
Olefin functionalization via qunione diazides (2014)
Olefin Hydroamination with nitroarenes (2015)
Hydromethylation of Unactivated Olefins (2015)
Anomeric Nitroamide Enabled, Cobalt Catalyzed Alkene Hydronitration

Radical Chemistry

General Redox-Neutral Platform for Radical Cross-Coupling (2024)
Practical Radical cyclization with Arylboronic Acids and Trifluoroborates (2011)
Fe-Catalyzed C–C Bond Construction from Olefins via Radicals
Sulfone enabled, radical cross-coupling resulting sp3-rich (fluoro)alkylated scaffolds (2018)
General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling (2018)
Ni-catalyzed/Ag-nanoparticle-modified electrodes for C–C sp–sp bond formation

Decarboxylative Coupling

Decarboxylative Borylation (2017)
Decarboxylative Alkenylation (2017)
Decarboxylative Alkynylation (2017)
Cu-Catalyzed Decarboxylative Borylation (2018)
Ni-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers (2023)
Ni-Catalyzed Enantioselective Decarboxylative Acylation (2023)
Stereocontrolled Radical Thiophosphorylation (2023)
Carbon Quaternization of RAEs and Olefins by Decarboxylative Coupling (2023)
Functionalized Olefin Cross-Coupling to Construct Carbon-Carbon Bonds
C–C cross-coupling of heteroatom-substituted olefins with e-deficient olefins
Ni-Catalyzed Aryl-Alkyl Cross-Coupling of 2° RAEs (2016)
Alkyl-Alkyl Cross-Coupling Enabled by RAEs and Alkylzinc Reagents (2016)
Ni-catalyzed cross-coupling of RAEs with Boronic Acids (2016)
Fe-catalyzed cross-coupling of RAEs (2016)
Ni-Catalyzed Enantioselective Dialkyl Carbinol Synthesis via Decarboxylative Cross-Coupling (2022)
Direct Carbon Isotope Exchange Through Decarboxylative Carboxylation (2019)

Simplifying Oligonucleotide Synthesis

P(V) reagents: chiral phosphorothioate synthesis (2018)
(+/-)-PI Reagent for the synthesis of P-Chiral Phosphines and Methyl-phosphonate oligonucleotides (2020)
P(V)-Platform for Oligonucleotide Synthesis (2021)
(+/-)-PSI Reagent for Enantioselective Synthesis of Thiophosphates (2021)
Mild and Chemoselective Phorsphorylation of Alcohols Using a Ψ-Reagent (2021)
Stereocontrolled Access to Thioisosteres of Nucleoside Di- and Triphosphates (2023)

Simplifying Peptide Synthesis

CITU—reagent for peptide synthesis and decarboxylative cross-coupling (2017)
Thermodynamic peptide macrocyclization (2017)
General method for chemoselective, and modular functionalization of serine residues (2020)

Halogenation

Direct difluoromethylation via Zn(SO₂CF₂H)₂
N–X Anomeric Amides as Electrophilic Halogenation Reagents (2023)
Guanidine-based chlorinating reagent, CBMG or “Palau’chlor” (2014)
Regioselective bromination of N-oxides (2013)

Strain Release

Strain-release amination (2016)
Stereospecific strain-release cyclopentylation of amines, alcohols, thiols, carboxylic acids, and other heteroatoms (2017)
Enantiocontrolled Azetidine Library Synthesis via Strain Release Functionalization of 1-Azabicyclobutanes (2024)

Electrochemical methods

Allylic C–H oxidation
Electrochemical Oxidation of Unactivated C–H Bonds
Electrochemical Ni-catalyzed amination
Reductive electrosynthesis (electrochemical Birch reduction)
Electrochemically Driven, Ni-Catalyzed Aryl Amination
Electrochemical C(sp3)-H Fluorination
Electrochemically Driven Desaturation of Carbonyl Compounds
Electrochemical Cyclobutane Synthesis in Flow
Electrochemical Decarboxylative N‑Alkylation of Heterocycles
Electroreductive Olefin-Ketone Coupling
Electrochemical Borylation of Carboxylic Acids
Electrochemical Nozaki–Hiyama–Kishi Coupling
Chemoselective Electrosynthesis via rapid alternating polarity (rAP)
Co-Electrocatalytic H.A.T. for Functionalization of Unsaturated C-C Bonds
Ni-Electrocatalytic C(sp3)–C(sp3) Doubly Decarboxylative Coupling
Chemoselective, Metal-free, (Hetero)Arene Electroreduction Enabled by Rapid Alternating Polarity
Decarboxylative Arylation via Ag-Ni Electrocatalysis
Chemoselective Ni-Electrocatalytic Sulfinylation of Aryl Halides
Waveform-Controlled Electrosynthesis
Electrocatalytic decarboxylative cross-coupling
Ni-Electrocatalytic Enantioselective Doubly Decarboxylative C(sp3)–C(sp3) Cross Coupling
N-Ammonium Ylide Mediators for Electrochemical C–H Oxidation
Electrochemical Decarboxylative Olefination (w/ Alternating Polarity)
Electroreductive Synthesis of Nickel(0) Complexes
Electrocatalytic Asymmetric Nozaki–Hiyama–Kishi Decarboxylative Coupling
Ni-electrocatalytic Modular Access to Enantiopure 1,2-Aminoalcohols decarboxylative arylation
Ni-Electrocatalytic Cross-Coupling Access to Targeted Protein Degraders
Ni/Ag-electrocatalytic Cross-Coupling Synthesis of Unnatural Amino Acids
Enantio and chemoselective electrocatalytic radical Cross Coupling for aminoalcohol Synthesis
Triply Convergent Ni-Electrocatalytic Assembly of 1,1-diaryl Cyclobutanes, Azetidines, and Oxetanes
Hindered Dialkyl Ether Synthesis (2019)
Chemoselective, Scalable Nickel-Electrocatalytic O-Arylation of Alcohols

Misc

Direct Coupling of Indoles with Carbonyl Compounds (2004)
One-Step Synthesis of 4,5-Disubstituted Pyrimidines (2006)
Intermolecular Enolate Heterocoupling (2008)
Direct arylation of indoles (2009)
Direct arylation of e-deficient heterocyles (2010)
Nickel-Promoted Diene/Alkyne Cooligomerization (2012)
Synthesis of 1,2-difunctionalized bicyclopentanes (2020)
Regioselective Synthesis of C4-Alkylated Pyridines (2021)

Reagents developed

(+/-)-PI Reagent
(+/-)-PSI Reagent
CBMG or “Palau’chlor”
CITU
Zinc sulphinate salts
- Zinc trifluoromethanesulphinate (TFMS), zinc difluoromethanesulphinate (DFMS), zinc trifluoroethanesulphinate (TFES), zinc monofluoromethanesulphinate (MFMS), zinc isopropylsulphinate (IPS), zinc triethyleneglycolsulphinate (TEGS)
Among others, listed at Sigma Aldrich

Publications

Phil S. Baran has authored and co-authored nearly 300 research publications and has an h-index of 126 with over 50,000 citations across his group's publications. Articles authored by Baran and his group can be found in numerous prestigious journals including Science, Nature, Journal of American Chemical Society (JACS), Angewandte Chemie, Journal of Organic Chemistry (JOC), among several others.

Baran co-wrote the digital interactive reference text The Portable Chemist’s Consultant: A Survival Guide for Discovery, Process, and Radiolabeling as well as several book chapters and forewords.

Community engagement

Skaggs Graduate School Commencement Ceremony (2024)
Reddit AMA (2016)
"What Makes a Good Chemist"

Awards and honors

Highly Cited Researcher, yearly, 2014–2024
Edison Patent Award, 2023
Horizon Discovery Prize, Royal Society of Chemistry, 2022
Danisco Science Excellence Medal Award, 2022
Bristol Chemical Synthesis Syngenta Award, 2021

Janssen Prize for Creativity, 2020
Inhoffen Medal, 2019
Manchot Research Professorship, 2017
Member, The National Academy of Sciences, 2017
Emanuel Merck Lectureship, 2017
Mukaiyama Award, 2014
MacArthur Fellowship, 2013
Royal Society of Chemistry Synthetic Organic Chemistry Award, 2013
ACS San Diego Section Distinguished Scientist Award, 2012
ISHC Katritzky Heterocyclic Chemistry Award, 2011
Thieme–IUPAC Prize in Synthetic Organic Chemistry, 2010
ACS Award in Pure Chemistry, 2010
Sackler Prize, 2009
Novartis Lecturer, 2007–2008
Hirata Gold Medal, 2007
National Fresenius Award, 2007
Pfizer Award for Creativity in Organic Chemistry, 2006
Beckman Young Investigators Award, 2006
Alfred P. Sloan Foundation Fellow, 2006–2008
BMS Unrestricted "Freedom to Discover" Grant, 2006–2010
NSF Career, 2006–2010
Eli-Lilly Young Investigator Award, 2005–2006
AstraZeneca Excellence in Chemistry Award, 2005
DuPont Young Professor Award, 2005
Roche Excellence in Chemistry Award, 2005
Amgen Young Investigator Award, 2005
Searle Scholar Award, 2005
GlaxoSmithKline Chemistry Scholar Award, 2005–2006
Nobel Laureate Signature Award for Graduate Education in Chemistry, ACS, 2003
National Institutes of Health Post-Doctoral Fellowship Award, Harvard, 2001–2003
Hoffmann-La Roche Award for Excellence in Organic Chemistry, 2000
Lesly Starr Shelton Award for Excellence in Chemistry Graduate Studies, 2000
National Science Foundation Pre-Doctoral Fellowship Award, Scripps, 1998–2001

References

The Baran Laboratory Archived June 6, 2017, at the Wayback Machine, Scripps Research Institute
"Baran Lab". Retrieved August 27, 2023.
^ "Phil S. Baran" (PDF). Retrieved August 27, 2023.
"Baran Group – Professor Product Portal". Sigma-Aldrich.
^ Peplow, Mark (2014). "The sultan of synthesis". Features. Chemistry World. Vol. 11. Royal Society of Chemistry. ISSN 1473-7604. OCLC 5585253041. Retrieved November 12, 2024.
"Former Group Members | Baran Lab". Retrieved November 20, 2024.
"Philip Baran | Scripps Research". www.scripps.edu. Retrieved November 20, 2024.
"Phil S. Baran | American Academy of Arts and Sciences". www.amacad.org. October 8, 2024. Retrieved November 20, 2024.
^ "About Phil S Baran | Baran Lab". Retrieved November 20, 2024.
"About". Sirenas. Retrieved November 20, 2024.
"About Us". Vividion Therapeutics. Retrieved November 20, 2024.
"Bayer acquires small molecule startup Vividion Therapeutics for up to $2 billion". Chemical & Engineering News. Retrieved November 20, 2024.
"News". Elsie Biotechnologies. Retrieved November 20, 2024.
"About". Galileo Biosystems. Retrieved November 20, 2024.
PhD, Kevin Davies (August 22, 2017). "Electrifying Catalysis: IKA Takes Bite Out of Apple to Launch Electrochemistry Product". GEN - Genetic Engineering and Biotechnology News. Retrieved November 20, 2024.
Hickman, Daniel (August 24, 2017). "Dawn of a New Age in Synthetic Organic Electrochemistry". ChemistryViews. Retrieved November 20, 2024.
"Publications | Baran Lab". Retrieved November 20, 2024.
Gaich, Tanja; Baran, Phil S. (July 16, 2010). "Aiming for the Ideal Synthesis". The Journal of Organic Chemistry. 75 (14): 4657–4673. doi:10.1021/jo1006812. ISSN 0022-3263.
Hendrickson, James B. (October 1, 1975). "Systematic synthesis design. IV. Numerical codification of construction reactions". Journal of the American Chemical Society. 97 (20): 5784–5800. doi:10.1021/ja00853a023. ISSN 0002-7863.
Smith, Brendyn P.; Truax, Nathanyal J.; Pollatos, Alexandros S.; Meanwell, Michael; Bedekar, Pranali; Garrido-Castro, Alberto F.; Baran, Phil S. (May 6, 2024). "Total Synthesis of Dragocins A−C through Electrochemical Cyclization". Angewandte Chemie International Edition. 63 (19): e202401107. doi:10.1002/anie.202401107. ISSN 1433-7851. PMC 11619770. PMID 38358802.
"Phil Baran". scholar.google.com. Retrieved November 12, 2024.
Gianatassio, Ryan; Ishihara, Yoshihiro; Baran, Phil S. (October 20, 2014), "Sodium 1,1-Difluoroethanesulfinate", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–2, doi:10.1002/047084289x.rn01783, ISBN 978-0-470-84289-8, retrieved November 12, 2024
Gianatassio, Ryan; Ishihara, Yoshihiro; Baran, Phil S. (October 20, 2014), "Zinc Difluoromethanesulfinate", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–3, doi:10.1002/047084289x.rn01787, ISBN 978-0-470-84289-8, retrieved November 12, 2024
Ishihara, Yoshihiro; Gianatassio, Ryan; Baran, Phil S. (October 20, 2014), "Zinc Isopropylsulfinate", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–3, doi:10.1002/047084289x.rn01785, ISBN 978-0-470-84289-8, retrieved November 12, 2024
Ishihara, Yoshihiro; Gianatassio, Ryan; Baran, Phil S. (October 20, 2014), "Zinc Trifluoromethanesulfinate", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–3, doi:10.1002/047084289x.rn01786, ISBN 978-0-470-84289-8, retrieved November 12, 2024
Pan, Chung-Mao; Ishihara, Yoshihiro; Baran, Phil S. (March 31, 2016), "Palau'chlor", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–2, doi:10.1002/047084289x.rn01901, ISBN 978-0-470-84289-8, retrieved November 12, 2024
Li, Jie Jack; Limberakis, Chris; Pflum, Derek A. (January 10, 2008). Modern Organic Synthesis in the Laboratory. Oxford University Press. doi:10.1093/oso/9780195187984.001.0001. ISBN 978-0-19-518798-4.
Li, Jie Jack (September 28, 2006), "Cardiovascular Drugs: From Nitroglycerin to Lipitor", Laughing Gas, Viagra, and Lipitor, Oxford University Press, doi:10.1093/oso/9780195300994.003.0008, ISBN 978-0-19-530099-4, retrieved November 12, 2024
Li, Jie Jack, ed. (March 30, 2009). Name Reactions for Homologations, Part I. Hoboken, NJ, USA: John Wiley & Sons, Inc. doi:10.1002/9780470487020. ISBN 978-0-470-48702-0.
"Scripps Research scientists make annual Highly Cited Researchers list". www.scripps.edu. Retrieved November 21, 2024.
Merck Group
"Phil S. Baran". Arnold and Mabel Beckman Foundation. Archived from the original on August 2, 2018. Retrieved August 1, 2018.

External links

Phil Baran: Molecule Magician, The Scientist Magazine
The sultan of synthesis, Chemistry World, Royal Society of Chemistry
Evolution from Academia to Industry – Interview with Professor Phil S. Baran, Oxbridge Biotech Roundtable

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