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| Philip Seeman | |
|---|---|
| Born | (1934-02-08)8 February 1934 Winnipeg, Manitoba, Canada |
| Died | 9 January 2021(2021-01-09) (aged 86) Toronto, Ontario, Canada |
| Awards | Order of Canada |
Philip Seeman, OC FRSC (8 February 1934 – 9 January 2021) was a Canadian schizophrenia researcher and neuropharmacologist, known for his research on dopamine receptors.
Career
Born in Winnipeg, Manitoba, Seeman was raised in Montreal. He received a Bachelor of Science degree, honours physics & physiology (1955), a Master of Science degree, physiology of transport & secretion (1956), and a Doctor of Medicine (1960) from McGill University. In 1966, he received a Ph.D. in life sciences from Rockefeller University under the supervision of George Emil Palade.
In 1967, Seeman became an assistant professor in the Department of Pharmacology at the University of Toronto. In 1970, he was appointed a professor.
In 1974, having spent years in search of the binding site of antipsychotic medication, he discovered the dopamine D2 receptor, the basis for the dopamine hypothesis of schizophrenia. His discoveries also helped advance research on other diseases involving dopamine, such as Parkinson's disease and Huntington's disease.
In 2001, he was made an Officer of the Order of Canada "for his research on dopamine receptors and their involvement in diseases such as schizophrenia, Parkinson's and Huntington's".
In 1985, he was made a Fellow of the Royal Society of Canada.
He was married to Dr. Mary V. Seeman.
Notes
- "Philip SEEMAN". The Globe and Mail. Retrieved 19 January 2021.
- ^ Peters, Diane (27 January 2021). "Researcher Philip Seeman shed new light on biology of schizophrenia". The Globe and Mail. Retrieved 15 August 2024.
- P. Seeman, M. Chau-Wong, J. Tedesco & K. Wong (November 1975). "Brain receptors for antipsychotic drugs and dopamine: direct binding assays". Proceedings of the National Academy of Sciences of the United States of America. 72 (11): 4376–4370. Bibcode:1975PNAS...72.4376S. doi:10.1073/pnas.72.11.4376. PMC 388724. PMID 1060115.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - "People". CMAJ. 151 (8): 1186–1187. 1994. PMC 1337253.
- Order of Canada citation
- "Science & Medicine - Science & Medicine". www.sciandmed.com. Archived from the original on 2011-07-16.
- "Most Misplaced Pages profiles are about men – these women in Australia are hoping to change that". SBS News. Retrieved 27 July 2019.
References
- Madras, B.K. (2013). "History of the discovery of the antipsychotic dopamine D2 receptor: A basis for the dopamine hypothesis of schizophrenia". Journal of the History of the Neurosciences: Basic and Clinical Perspectives. 22 (1): 62–78. doi:10.1080/0964704x.2012.678199. PMID 23323533. S2CID 12002684.
- Seeman, P. (2011). "All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2High receptors". CNS Neuroscience & Therapeutics. 17 (2): 118–132. doi:10.1111/j.1755-5949.2010.00162.x. PMC 6493870. PMID 20560996.
- P. Seeman (2010). "Dopamine D2 Receptors as Treatment Targets in Schizophrenia. Clinical Schizophrenia & Related Psychoses April: 56-73.
- P. Seeman (2007), Scholarpedia, 2(10): 3634 doi.4249/scholarpedia.3634
- Seeman, P. (2006). "Targeting the dopamine D2 receptor in schizophrenia". Expert Opinion on Therapeutic Targets. 10 (4): 515–531. doi:10.1517/14728222.10.4.515. PMID 16848689. S2CID 30902536.
- Seeman, P.; Weinshenker, D.; Quirion, R.; Srivastava, L.; Bhardwaj, S.K.; Grandy, D.K.; Premont, R.; Sotnikova, T.; Boksa, P.; El-Ghundi, M.; O'Dowd, B.F.; George, S.R.; Perreault, M.L.; Mannisto, P.T.; Robinson, S.; Palmiter, R.D.; Tallerico, T. (2005). "Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis". Proceedings of the National Academy of Sciences USA. 102 (9): 3513–3518. Bibcode:2005PNAS..102.3513S. doi:10.1073/pnas.0409766102. PMC 548961. PMID 15716360.
- Seeman, P.; Chau-Wong, M.; Tedesco, J.; Wong, K. (1975). "Brain receptors for antipsychotic drugs and dopamine: Direct binding assays". Proceedings of the National Academy of Sciences, USA. 72 (11): 4376–4380. Bibcode:1975PNAS...72.4376S. doi:10.1073/pnas.72.11.4376. PMC 388724. PMID 1060115.
External links
- Home Page of Philip Seeman's Laboratory
- Probing the Biology of Psychosis, Schizophrenia, and Antipsychotics: An Expert Interview With Dr. Philip Seeman, MD, PhD – an interview on the Medscape website
- Schizophrenia – an essay by Philip Seeman, November 2001