| Phosphatidylglycerophosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | PAP2 | ||||||||
| Pfam | PF01569 | ||||||||
| OPM superfamily | 409 | ||||||||
| OPM protein | 5jwy | ||||||||
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| phosphatidylglycerophosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.27 | ||||||||
| CAS no. | 9033-46-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme phosphatidylglycerophosphatase (EC 3.1.3.27) catalyzes the following reaction:
- phosphatidylglycerophosphate + H2O phosphatidylglycerol + phosphate
phosphatidylglycerol + phosphateThis enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is phosphatidylglycerophosphate phosphohydrolase. Other names in common use include phosphatidylglycerol phosphate phosphatase, phosphatidylglycerol phosphatase, and PGP phosphatase. It participates in glycerophospholipid metabolism.
This is a family of proteins that acts as a mitochondrial phosphatase in cardiolipin biosynthesis. Cardiolipin is a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes.
References
- Chang YY, Kennedy EP (1967). "Phosphatidyl glycerophosphate phosphatase". J. Lipid Res. 8 (5): 456–62. PMID 4292860.
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