Pietikäinen is a Finnish surname. Notable people with the surname include:
- Aatto Pietikäinen (1921–1966), Finnish ski jumper
- Matti Pietikäinen (1927–1967), Finnish ski jumper, brother of Aatto
- Matti Pietikäinen (academic), Finnish computer scientist
- Sirpa Pietikäinen (1959-), Finnish politician
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