Pietrangelo is both an Italian surname and given name. Notable people with the name include:
- Alex Pietrangelo (born 1990), Canadian ice hockey defenceman
- Amelia Pietrangelo (born 1993), Canadian soccer striker
- Frank Pietrangelo (born 1964), Canadian ice hockey goaltender
- Pietrangelo Pettenò (born 1960), Italian politician from Veneto
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