Pilla is an Italian and Indian-origin surname. Notable persons with the surname include:
- Anthony Michael Pilla (1932–2021), American bishop
- Carmino de Pilla (born 1912), Brazilian basketball player
- conte Marco Pilla (born 1981),Italian nobleman,heraldic artist
- Franca Pilla (born 1920), former Italian first lady
- Leopoldo Pilla (1805–1848), Italian geologist
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