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In enzymology, a prenylcysteine oxidase (EC 1.8.3.5) is an enzyme that catalyzes the chemical reaction

an S-prenyl-L-cysteine + O₂ + H₂O ${\displaystyle \rightleftharpoons }$ a prenal + L-cysteine + H₂O₂

The 3 substrates of this enzyme are S-prenyl-L-cysteine, O₂, and H₂O, whereas its 3 products are prenal, L-cysteine, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with oxygen as acceptor. The systematic name of this enzyme class is S-prenyl-L-cysteine:oxygen oxidoreductase. This enzyme is also called prenylcysteine lyase.

Human protein and gene

• Prenylcysteine oxidase 1, symbol PCYOX1, gene on chromosome 2

See also

• Hemithioacetals in nature, for mechanism of action
• Flavin adenine dinucleotide, cofactor of the enzyme
• Prenylation, a process forming S-prenyl-L-cysteine

References

• Zhang L, Tschantz WR, Casey PJ (1997). "Isolation and characterization of a prenylcysteine lyase from bovine brain". J. Biol. Chem. 272 (37): 23354–9. doi:10.1074/jbc.272.37.23354. PMID 9287348.
• Tschantz WR, Digits JA, Pyun HJ, Coates RM, Casey PJ (2001). "Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase". J. Biol. Chem. 276 (4): 2321–4. doi:10.1074/jbc.C000616200. PMID 11078725.

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