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In enzymology, a putrescine N-methyltransferase (EC 2.1.1.53) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + putrescine ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + N-methylputrescine

Thus, the two substrates of this enzyme are S-adenosyl methionine and putrescine, whereas its two products are S-adenosylhomocysteine and N-methylputrescine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:putrescine N-methyltransferase. This enzyme is also called putrescine methyltransferase. This enzyme participates in alkaloid biosynthesis ii.

This enzyme is important in the synthesis of many plant alkaloids. It evolved from spermidine synthase.

References

1. Biastoff S, Brandt W, Dräger B (2009-10-01). "Putrescine N-methyltransferase--the start for alkaloids". Phytochemistry. Evolution of Metabolic Diversity. 70 (15–16): 1708–18. doi:10.1016/j.phytochem.2009.06.012. PMID 19651420.
2. Junker A, Fischer J, Sichhart Y, Brandt W, Dräger B (2013-01-01). "Evolution of the key alkaloid enzyme putrescine N-methyltransferase from spermidine synthase". Frontiers in Plant Science. 4: 260. doi:10.3389/fpls.2013.00260. PMC 3725402. PMID 23908659.

• Mizusaki S, Tanabe Y, Noguchi M, Tamaki E (1971). "Phytochemical studies on tobacco alkaloids. XIV. The occurrence and properties of putrescine N-methyltransferase in tobacco roots". Plant Cell Physiol. 12: 633–640.

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