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RELT
Identifiers
Aliases	RELT, TNFRSF19L, TRLT, RELT tumor necrosis factor receptor, TNF receptor, RELT TNF receptor, AI3C
External IDs	OMIM: 611211; MGI: 2443373; HomoloGene: 13151; GeneCards: RELT; OMA:RELT - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.4 Start 73,376,399 bp End 73,397,474 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E2 Start 100,495,054 bp End 100,512,653 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood bone marrow cells spleen gastrocnemius muscle muscle of thigh appendix lymph node upper lobe of left lung Top expressed in granulocyte bone marrow quadriceps femoris muscle spleen muscle tissue skeletal muscle tissue islet of Langerhans Hypothalamus female urethra placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function tumor necrosis factor-activated receptor activity protein binding Cellular component cytoplasm integral component of membrane plasma membrane integral component of plasma membrane membrane nucleus perinuclear region of cytoplasm Biological process multicellular organism development regulation of apoptotic process apoptotic signaling pathway response to lipopolysaccharide inflammatory response regulation of cell population proliferation immune response tumor necrosis factor-mediated signaling pathway apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84957 320100 Ensembl ENSG00000054967 ENSMUSG00000008318 UniProt Q969Z4 Q8BX43 RefSeq (mRNA) NM_032871 NM_152222 NM_177073 NM_001358914 RefSeq (protein) NP_116260 NP_689408 NP_796047 NP_001345843 Location (UCSC) Chr 11: 73.38 – 73.4 Mb Chr 7: 100.5 – 100.51 Mb PubMed search
Wikidata
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Tumor necrosis factor receptor superfamily member 19L is a protein that in humans is encoded by the RELT gene.

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000054967 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000008318 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sica GL, Zhu G, Tamada K, Liu D, Ni J, Chen L (Apr 2001). "RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB". Blood. 97 (9): 2702–7. doi:10.1182/blood.V97.9.2702. PMID 11313261. S2CID 6347356.
6. Bossen C, Ingold K, Tardivel A, Bodmer JL, Gaide O, Hertig S, Ambrose C, Tschopp J, Schneider P (May 2006). "Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human" (PDF). J Biol Chem. 281 (20): 13964–71. doi:10.1074/jbc.M601553200. PMID 16547002.
7. Polek TC, Talpaz M, Spivak-Kroizman TR (Sep 2006). "TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis". Biochem Biophys Res Commun. 349 (3): 1016–24. doi:10.1016/j.bbrc.2006.08.118. PMID 16950202.
8. Cusick JK, Xu LG, Bin LH, Han KJ, Shu HB (Jan 2006). "Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1". Biochem Biophys Res Commun. 340 (2): 535–43. doi:10.1016/j.bbrc.2005.12.033. PMID 16389068.
9. ^ "Entrez Gene: TNFRSF19L tumor necrosis factor receptor superfamily, member 19-like".

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