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RGL2
Identifiers
Aliases	RGL2, HKE1.5, KE1.5, RAB2L, ral guanine nucleotide dissociation stimulator like 2
External IDs	OMIM: 602306; MGI: 107483; HomoloGene: 3494; GeneCards: RGL2; OMA:RGL2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.32 Start 33,291,654 bp End 33,298,942 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 B1 Start 34,148,517 bp End 34,156,661 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen right uterine tube Pituitary Gland anterior pituitary right lobe of thyroid gland fundus left lobe of thyroid gland prostate right adrenal cortex salivary gland Top expressed in granulocyte neural layer of retina lip yolk sac thymus external carotid artery saccule internal carotid artery Rostral migratory stream ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding guanyl-nucleotide exchange factor activity Cellular component intracellular anatomical structure cellular component Biological process small GTPase mediated signal transduction Ras protein signal transduction signal transduction negative regulation of cardiac muscle cell apoptotic process regulation of Ral protein signal transduction positive regulation of phosphatidylinositol 3-kinase signaling regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5863 19732 Ensembl ENSG00000228736 ENSG00000237441 ENSG00000237825 ENSG00000224841 ENSG00000206282 n/a ENSMUSG00000041354 UniProt O15211 Q61193 RefSeq (mRNA) NM_001243738 NM_004761 NM_009059 RefSeq (protein) NP_001230667 NP_004752 NP_033085 Location (UCSC) Chr 6: 33.29 – 33.3 Mb Chr 17: 34.15 – 34.16 Mb PubMed search
Wikidata
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Ral guanine nucleotide dissociation stimulator-like 2 is a protein that in humans is encoded by the RGL2 gene.

Interactions

RGL2 has been shown to interact with HRAS.

References

1. ^ ENSG00000237441, ENSG00000237825, ENSG00000224841, ENSG00000206282 GRCh38: Ensembl release 89: ENSG00000228736, ENSG00000237441, ENSG00000237825, ENSG00000224841, ENSG00000206282 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000041354 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (January 1997). "Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS". Cytogenet Cell Genet. 74 (4): 263–5. doi:10.1159/000134431. PMID 8976381.
6. "Entrez Gene: RGL2 ral guanine nucleotide dissociation stimulator-like 2".
7. Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
8. Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC (November 1996). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1". J. Biol. Chem. 271 (47): 29903–8. doi:10.1074/jbc.271.47.29903. PMID 8939933.

Further reading

• Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC (1997). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1". J. Biol. Chem. 271 (47): 29903–8. doi:10.1074/jbc.271.47.29903. PMID 8939933.
• Herberg JA, Sgouros J, Jones T, Copeman J, Humphray SJ, Sheer D, Cresswell P, Beck S, Trowsdale J (1998). "Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC". Eur. J. Immunol. 28 (2): 459–67. doi:10.1002/(SICI)1521-4141(199802)28:02<459::AID-IMMU459>3.0.CO;2-Z. PMID 9521053. S2CID 35772444.
• Herberg JA, Beck S, Trowsdale J (1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC". J. Mol. Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID 9545376.
• Ando A, Kikuti YY, Abe K, Shigenari A, Kawata H, Ikemura T, Kimura M, Inoko H (1999). "cDNA cloning, northern hybridization, and mapping analysis of a putative GDS-related protein gene at the centromeric ends of the human and mouse MHC regions". Immunogenetics. 49 (4): 354–6. doi:10.1007/s002510050504. PMID 10079301. S2CID 30077097.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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