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RPE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OVQ, 3OVR, 3OVP, 3QC3
Identifiers
Aliases	RPE, RPE2-1, ribulose-5-phosphate-3-epimerase
External IDs	OMIM: 180480; MGI: 1913896; HomoloGene: 12005; GeneCards: RPE; OMA:RPE - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q34 Start 210,002,565 bp End 210,022,260 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C3 Start 66,739,990 bp End 66,758,964 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans Achilles tendon epithelium of colon rectum bone marrow cells Brodmann area 23 endothelial cell ventricular zone stromal cell of endometrium right adrenal cortex Top expressed in saccule seminal vesicula brown adipose tissue granulocyte intercostal muscle gastric mucosa otic placode mucous cell of stomach secondary oocyte duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function racemase and epimerase activity, acting on carbohydrates and derivatives ribulose-phosphate 3-epimerase activity catalytic activity isomerase activity protein homodimerization activity metal ion binding identical protein binding Cellular component cytosol extracellular exosome Biological process pentose catabolic process pentose-phosphate shunt metabolism pentose-phosphate shunt, non-oxidative branch cellular carbohydrate metabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6120 66646 Ensembl ENSG00000197713 ENSMUSG00000026005 UniProt Q96AT9 Q8VEE0 RefSeq (mRNA) NM_001278282 NM_001278283 NM_001278285 NM_001278286 NM_001278288 NM_001278289 NM_006916 NM_199229 NM_001318926 NM_001318927 NM_001318928 NM_001318929 NM_001318930 NM_001318931 NM_025683 NM_001310642 NM_001310643 NM_001310644 RefSeq (protein) NP_001265211 NP_001265212 NP_001265214 NP_001265215 NP_001265217 NP_001265218 NP_001305855 NP_001305856 NP_001305857 NP_001305858 NP_001305859 NP_001305860 NP_008847 NP_954699 NP_001297571 NP_001297572 NP_001297573 NP_079959 Location (UCSC) Chr 2: 210 – 210.02 Mb Chr 1: 66.74 – 66.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ribulose-phosphate 3-epimerase is an enzyme that in humans is encoded by the RPE gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000197713 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000026005 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RPE ribulose-5-phosphate-3-epimerase".

Further reading

• Boss GR, Pilz RB (1985). "Phosphoribosylpyrophosphate synthesis from glucose decreases during amino acid starvation of human lymphoblasts". J. Biol. Chem. 260 (10): 6054–9. doi:10.1016/S0021-9258(18)88936-0. PMID 2581946.
• Miyazaki K, Yamanaka T, Ogasawara N (1989). "Interstitial deletion 2q32.1----q34 in a child with half normal activity of ribulose 5-phosphate 3-epimerase (RPE)". J. Med. Genet. 25 (12): 850–1. doi:10.1136/jmg.25.12.850. PMC 1051616. PMID 3236368.
• Dallapiccola B, Novelli G, Giannotti A (1988). "Deletion 2q31.3----2q33.3: gene dosage effect of ribulose 5-phosphate 3-epimerase". Hum. Genet. 79 (1): 92. doi:10.1007/BF00291721. PMID 3366467. S2CID 12134011.
• Spencer N, Hopkinson DA (1980). "Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE)". Ann. Hum. Genet. 43 (4): 335–42. doi:10.1111/j.1469-1809.1980.tb01567.x. PMID 7396409. S2CID 24547339.
• Stanchi F, Bertocco E, Toppo S, et al. (2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703. S2CID 21397515.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Krull M, Brosius J, Schmitz J (2005). "Alu-SINE exonization: en route to protein-coding function". Mol. Biol. Evol. 22 (8): 1702–11. doi:10.1093/molbev/msi164. PMID 15901843.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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