Ubiquitin A-52 residue ribosomal protein fusion product 1

(Redirected from RPL40) Human protein

UBA52

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
2LJ5, 2MBH, 2MJB, 2MUR, 2RSU, 4HJK, 4JIO, 4P4H, 4PIG, 4PIH, 4PIJ, 4RF0, 4RF1, 4S1Z, 4UG0, 4V6X, 5AJ0, 4UJD, 4D67, 4UJC, 3J7P, 3J7Q, 4XKL, 3J92, 4D5Y, 3J7O, 3J7R, 3PHD, 2KOX, 4UJE, 5A5B, 2N3V, 2N3U, 2N3W, 2NBD, 2NBE, 3VDZ, 5HPS, 3I3T, 5HPT, 5JBV, 5HPL, 5HPK, 5J8P

Identifiers

Aliases

UBA52, CEP52, HUBCEP52, L40, RPL40, Ubiquitin A-52 residue ribosomal protein fusion product 1

External IDs

OMIM: 191321; MGI: 3644625; HomoloGene: 68307; GeneCards: UBA52; OMA:UBA52 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)

Band	19p13.11	Start	18,571,730 bp
Band	19p13.11	End	18,577,550 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

blood

right testis

left testis

granulocyte

sperm

stromal cell of endometrium

lymph node

left ovary

mononuclear cell

monocyte

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	structural constituent of ribosome protein binding protein tag ubiquitin protein ligase binding
Cellular component	cytoplasm endocytic vesicle membrane nucleus ribosome extracellular exosome endosome membrane lysosomal membrane extracellular space nucleoplasm mitochondrial outer membrane endoplasmic reticulum cytosol plasma membrane endoplasmic reticulum quality control compartment vesicle endoplasmic reticulum membrane host cell cytosolic large ribosomal subunit cytosolic small ribosomal subunit synapse
Biological process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest negative regulation of epidermal growth factor receptor signaling pathway interstrand cross-link repair nucleotide-excision repair, DNA damage recognition positive regulation of canonical Wnt signaling pathway tumor necrosis factor-mediated signaling pathway regulation of type I interferon production TRIF-dependent toll-like receptor signaling pathway Fc-epsilon receptor signaling pathway endosomal transport global genome nucleotide-excision repair NIK/NF-kappaB signaling G2/M transition of mitotic cell cycle stress-activated MAPK cascade transforming growth factor beta receptor signaling pathway macroautophagy negative regulation of canonical Wnt signaling pathway nucleotide-excision repair, DNA gap filling viral transcription error-free translesion synthesis regulation of tumor necrosis factor-mediated signaling pathway stimulatory C-type lectin receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway SRP-dependent cotranslational protein targeting to membrane JNK cascade regulation of transcription from RNA polymerase II promoter in response to hypoxia nucleotide-excision repair, DNA incision I-kappaB kinase/NF-kappaB signaling innate immune response Notch signaling pathway regulation of mRNA stability protein polyubiquitination negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II virion assembly positive regulation of NF-kappaB transcription factor activity anaphase-promoting complex-dependent catabolic process negative regulation of type I interferon production nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nucleotide-binding oligomerization domain containing signaling pathway intracellular transport of virus viral life cycle MyD88-dependent toll-like receptor signaling pathway error-prone translesion synthesis MAPK cascade fibroblast growth factor receptor signaling pathway ion transmembrane transport glycogen biosynthetic process positive regulation of apoptotic process translational initiation positive regulation of I-kappaB kinase/NF-kappaB signaling translesion synthesis transcription-coupled nucleotide-excision repair T cell receptor signaling pathway MyD88-independent toll-like receptor signaling pathway positive regulation of transcription by RNA polymerase II positive regulation of epidermal growth factor receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process regulation of signal transduction by p53 class mediator Wnt signaling pathway, planar cell polarity pathway nucleotide-excision repair, DNA incision, 5'-to lesion protein biosynthesis nucleotide-excision repair, preincision complex assembly rRNA processing Wnt signaling pathway ERBB2 signaling pathway nucleotide-excision repair, DNA duplex unwinding protein folding negative regulation of G2/M transition of mitotic cell cycle protein ubiquitination protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process entry of bacterium into host cell transmembrane transport regulation of necroptotic process membrane organization endoplasmic reticulum mannose trimming cellular iron ion homeostasis regulation of hematopoietic stem cell differentiation protein targeting to peroxisome cytokine-mediated signaling pathway modification-dependent protein catabolic process interleukin-1-mediated signaling pathway response to insecticide
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7311


665964

Ensembl


ENSG00000221983


n/a

UniProt


P62987


n/a

RefSeq (mRNA)

NM_001033930 NM_003333 NM_001321017 NM_001321018 NM_001321019
NM_001321020 NM_001321021 NM_001321022


n/a

RefSeq (protein)

NP_001029102 NP_001307946 NP_001307947 NP_001307948 NP_001307949
NP_001307950 NP_001307951 NP_003324


n/a

Location (UCSC)

Chr 19: 18.57 – 18.58 Mb

n/a

PubMed search

Wikidata

View/Edit Human

View/Edit Mouse

60S ribosomal protein L40 (RPL40) is a protein that in humans is encoded by the UBA52 gene.

Function

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N-terminus and ribosomal protein L40 at the C-terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome.

References

^ GRCh38: Ensembl release 89: ENSG00000221983 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Webb GC, Baker RT, Coggan M, Board PG (Jun 1994). "Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12". Genomics. 19 (3): 567–9. doi:10.1006/geno.1994.1108. PMID 8188300.
^ "Entrez Gene: UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1".

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