Rainio is a surname of Finnish origin. Notable people with the surname include:
- Aino Forsten (1885-1937), born Aina Rainio, Finnish politician and educator
- Jussi Rainio (1878-1918), Finnish journalist and politician
- Selma Rainio (1873-1939), Finnish missionary
- Väinö Rainio (1896-1979), Finnish athlete
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