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Regression (medicine)

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Regression in medicine is the partial or complete reversal of a disease's signs and symptoms.

  • Clinically, regression generally refers to a decrease in severity of symptoms without completely disappearing. At a later point, symptoms may return. These symptoms are then called recidive.
Mandard tumor regression grade (TRG), in this case showing rectal cancer.
  • In cancer, regression refers to a specific decrease in the size or extent of a tumour. In histopathology, histological regression is one or more areas within a tumor in which neoplastic cells have disappeared or decreased in number. In melanomas, this means complete or partial disappearance from areas of the dermis (and occasionally from the epidermis), which have been replaced by fibrosis, accompanied by melanophages, new blood vessels, and a variable degree of inflammation.

References

  1. Santos, Marisa D.; Silva, Cristina; Rocha, Anabela; Nogueira, Carlos; Castro-Poças, Fernando; Araujo, António; Matos, Eduarda; Pereira, Carina; Medeiros, Rui; Lopes, Carlos (2017). "Predictive clinical model of tumor response after chemoradiation in rectal cancer". Oncotarget. 8 (35): 58133–58151. doi:10.18632/oncotarget.19651. ISSN 1949-2553. PMC 5601639. PMID 28938543.
    -Figure 3- available via license: Creative Commons Attribution 3.0 Unported
  2. "Regression". NCI Dictionary of Cancer Terms. National Cancer Institute. Retrieved 31 August 2017.
  3. ^ Ribero, Simone; Gualano, Maria Rosaria; Osella-Abate, Simona; Scaioli, Giacomo; Bert, Fabrizio; Sanlorenzo, Martina; Balagna, Elena; Fierro, Maria Teresa; Macripò, Giuseppe; Sapino, Anna; Siliquini, Roberta; Quaglino, Pietro (2015). "Association of Histologic Regression in Primary Melanoma With Sentinel Lymph Node Status". JAMA Dermatology. 151 (12): 1301–1307. doi:10.1001/jamadermatol.2015.2235. ISSN 2168-6068. PMID 26332402.
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