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Reldesemtiv

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Chemical compound

Pharmaceutical compound
Reldesemtiv
Clinical data
Other namesCK-2127107
Legal status
Legal status
  • Investigational
Identifiers
IUPAC name
  • 1-methylamino]pyrimidin-5-yl]pyrrole-3-carboxamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC19H18F2N6O
Molar mass384.391 g·mol
3D model (JSmol)
SMILES
  • C1C(CC1(CNC2=NC=C(C=N2)N3C=CC(=C3)C(=O)N)C4=C(C=CC=N4)F)F
InChI
  • InChI=1S/C19H18F2N6O/c20-13-6-19(7-13,16-15(21)2-1-4-23-16)11-26-18-24-8-14(9-25-18)27-5-3-12(10-27)17(22)28/h1-5,8-10,13H,6-7,11H2,(H2,22,28)(H,24,25,26)
  • Key:MQXWPWOCXGARRK-UHFFFAOYSA-N

Reldesemtiv is an investigational new drug that is being evaluated to treat amyotrophic lateral sclerosis. It is a troponin activator.

References

  1. "Reldesemtiv - Astellas Pharma/Cytokinetics". AdisInsight. Springer Nature Switzerland AG.
  2. Collibee SE, Bergnes G, Chuang C, Ashcraft L, Gardina J, Garard M, et al. (October 2021). "Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function". Journal of Medicinal Chemistry. 64 (20): 14930–14941. doi:10.1021/acs.jmedchem.1c01067. PMID 34636234.


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