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SEC24D
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3EFO, 3EG9
Identifiers
Aliases	SEC24D, CLCRP2, SEC24 homolog D, COPII coat complex component
External IDs	OMIM: 607186; MGI: 1916858; HomoloGene: 40986; GeneCards: SEC24D; OMA:SEC24D - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q26 Start 118,722,823 bp End 118,838,683 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 G1 Start 123,061,104 bp End 123,159,290 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium jejunal mucosa islet of Langerhans ascending aorta right coronary artery Descending thoracic aorta right lobe of liver smooth muscle tissue body of pancreas tibia Top expressed in yolk sac calvaria ascending aorta aortic valve seminal vesicula duodenum epithelium of small intestine islet of Langerhans jejunum umbilical cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding SNARE binding zinc ion binding metal ion binding Cellular component cytoplasm endoplasmic reticulum membrane membrane Golgi membrane endoplasmic reticulum COPII vesicle coat cytosol ER to Golgi transport vesicle membrane cytoplasmic vesicle Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class I in utero embryonic development COPII vesicle coating protein transport intracellular protein transport vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport COPII-coated vesicle cargo loading Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9871 69608 Ensembl ENSG00000150961 ENSMUSG00000039234 UniProt O94855 n/a RefSeq (mRNA) NM_014822 NM_001318066 NM_027135 RefSeq (protein) NP_001304995 NP_055637 n/a Location (UCSC) Chr 4: 118.72 – 118.84 Mb Chr 3: 123.06 – 123.16 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Protein transport protein Sec24D is a protein that in humans is encoded by the SEC24D gene.

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000150961 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000039234 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
6. Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Apr 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J Biol Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.
7. ^ "Entrez Gene: SEC24D SEC24 related gene family, member D (S. cerevisiae)".

Further reading

• Tang BL, Kausalya J, Low DY, et al. (1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem. Biophys. Res. Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Watson P, Forster R, Palmer KJ, et al. (2005). "Coupling of ER exit to microtubules through direct interaction of COPII with dynactin". Nat. Cell Biol. 7 (1): 48–55. doi:10.1038/ncb1206. PMC 1592520. PMID 15580264.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Farhan H, Reiterer V, Korkhov VM, et al. (2007). "Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D". J. Biol. Chem. 282 (10): 7679–89. doi:10.1074/jbc.M609720200. PMID 17210573.

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