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SESN3
Identifiers
Aliases	SESN3, SEST3, sestrin 3
External IDs	OMIM: 607768; MGI: 1922997; HomoloGene: 14386; GeneCards: SESN3; OMA:SESN3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q21 Start 95,165,513 bp End 95,232,541 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A1 Start 14,186,363 bp End 14,244,397 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm lateral nuclear group of thalamus retinal pigment epithelium internal globus pallidus trigeminal ganglion mucosa of paranasal sinus epithelium of nasopharynx Achilles tendon spinal ganglia external globus pallidus Top expressed in ventromedial nucleus lateral septal nucleus molar olfactory tubercle saccule mammillary body ciliary body nucleus accumbens Amygdala retinal pigment epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity protein binding oxidoreductase activity, acting on peroxide as acceptor leucine binding Cellular component nucleus cytoplasm GATOR2 complex TORC2 complex Biological process regulation of response to reactive oxygen species negative regulation of TORC1 signaling response to insulin glucose homeostasis regulation of protein kinase B signaling TORC2 signaling regulation of insulin receptor signaling pathway cellular response to amino acid starvation cellular response to glucose starvation cellular response to amino acid stimulus positive regulation of macroautophagy cellular response to leucine cellular response to leucine starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 143686 75747 Ensembl ENSG00000149212 ENSMUSG00000032009 UniProt P58005 Q9CYP7 RefSeq (mRNA) NM_001271594 NM_144665 NM_030261 RefSeq (protein) NP_001258523 NP_653266 NP_084537 Location (UCSC) Chr 11: 95.17 – 95.23 Mb Chr 9: 14.19 – 14.24 Mb PubMed search
Wikidata
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Sestrin 3 is a protein that in humans is encoded by the SESN3 gene.

Function

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000149212 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032009 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Sestrin 3". Retrieved 2017-08-05.

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N (2010). "FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor". Dev. Cell. 18 (4): 592–604. doi:10.1016/j.devcel.2010.03.008. PMC 3031984. PMID 20412774.
• Zamkova M, Khromova N, Kopnin BP, Kopnin P (2013). "Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways". Cell Cycle. 12 (5): 826–36. doi:10.4161/cc.23723. PMC 3610730. PMID 23388456.
• Nascimento EB, Osler ME, Zierath JR (2013). "Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle". Am. J. Physiol. Endocrinol. Metab. 305 (11): E1408–14. doi:10.1152/ajpendo.00212.2013. PMC 3882372. PMID 24129397.
• Vakana E, Arslan AD, Szilard A, Altman JK, Platanias LC (2013). "Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells". PLOS ONE. 8 (11): e78780. Bibcode:2013PLoSO...878780V. doi:10.1371/journal.pone.0078780. PMC 3832611. PMID 24260131.
• Kang X, Petyaykina K, Tao R, Xiong X, Dong XC, Liangpunsakul S (2014). "The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury". Am. J. Physiol. Gastrointest. Liver Physiol. 307 (1): G58–65. doi:10.1152/ajpgi.00373.2013. PMC 4080163. PMID 24833709.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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