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SIGLEC5
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2ZG1, 2ZG2, 2ZG3
Identifiers
Aliases	SIGLEC5, CD170, CD33L2, OB-BP2, OBBP2, SIGLEC-5, sialic acid binding Ig like lectin 5
External IDs	OMIM: 604200; HomoloGene: 55783; GeneCards: SIGLEC5; OMA:SIGLEC5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.41 Start 51,610,960 bp End 51,630,401 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood bone marrow bone marrow cells granulocyte monocyte appendix lymph node right lung spleen duodenum n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding protein binding Cellular component integral component of membrane membrane plasma membrane secretory granule membrane tertiary granule membrane ficolin-1-rich granule membrane Biological process cell adhesion neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8778 n/a Ensembl ENSG00000268500 n/a UniProt O15389 n/a RefSeq (mRNA) NM_003830 NM_001384708 NM_001384709 n/a RefSeq (protein) NP_003821 n/a Location (UCSC) Chr 19: 51.61 – 51.63 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. SIGLEC5 has also been designated CD170 (cluster of differentiation 170).

References

1. ^ GRCh38: Ensembl release 89: ENSG00000268500 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Kim HS (Jun 1999). "Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (1–2): 96. doi:10.1159/000015227. PMID 10343116. S2CID 10581090.
4. "Entrez Gene: SIGLEC5 sialic acid binding Ig-like lectin 5".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Cornish AL, Freeman S, Forbes G, et al. (1998). "Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33". Blood. 92 (6): 2123–32. doi:10.1182/blood.V92.6.2123. PMID 9731071.
• Patel N, Brinkman-Van der Linden EC, Altmann SW, et al. (1999). "OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily". J. Biol. Chem. 274 (32): 22729–38. doi:10.1074/jbc.274.32.22729. PMID 10428856.
• Yousef GM, Ordon MH, Foussias G, Diamandis EP (2002). "Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes". Gene. 286 (2): 259–70. doi:10.1016/S0378-1119(02)00432-8. PMID 11943481.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Erickson-Miller CL, Freeman SD, Hopson CB, et al. (2003). "Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes". Exp. Hematol. 31 (5): 382–8. doi:10.1016/S0301-472X(03)00046-8. PMID 12763136.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Avril T, Freeman SD, Attrill H, et al. (2005). "Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation" (PDF). J. Biol. Chem. 280 (20): 19843–51. doi:10.1074/jbc.M502041200. PMID 15769739. S2CID 44764751.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Rapoport EM, Pazynina GV, Sablina MA, et al. (2006). "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides". Biochemistry Mosc. 71 (5): 496–504. doi:10.1134/S0006297906050051. PMID 16732727. S2CID 11537303.
• Biedermann B, Gil D, Bowen DT, Crocker PR (2007). "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors". Leuk. Res. 31 (2): 211–20. doi:10.1016/j.leukres.2006.05.026. PMID 16828866.
• Angata T, Hayakawa T, Yamanaka M, et al. (2006). "Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates". FASEB J. 20 (12): 1964–73. doi:10.1096/fj.06-5800com. PMID 17012248. S2CID 13740587.
• Zhuravleva MA, Trandem K, Sun PD (2007). "Structural Implications of Siglec-5-Mediated Sialoglycan Recognition". J. Mol. Biol. 375 (2): 437–47. doi:10.1016/j.jmb.2007.10.009. PMC 2245879. PMID 18022638.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Sialic acid-binding Ig-like lectin 5 (SIGLEC5)

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• Genes on human chromosome 19
• Clusters of differentiation
• SIGLEC
• Membrane protein stubs