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SOSTDC1
Identifiers
Aliases	SOSTDC1, ECTODIN, USAG1, CDA019, DAND7, sclerostin domain containing 1
External IDs	OMIM: 609675; MGI: 1913292; HomoloGene: 9154; GeneCards: SOSTDC1; OMA:SOSTDC1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p21.2 Start 16,461,481 bp End 16,530,580 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 A3 Start 36,364,138 bp End 36,368,451 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium hair follicle Epithelium of choroid plexus parotid gland skin of thigh skin of arm lower lobe of lung rectum sperm endothelial cell Top expressed in Epithelium of choroid plexus molar retinal pigment epithelium lumbar spinal ganglion sciatic nerve lip right kidney lateral recess human kidney Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function BMP binding BMP receptor activity Cellular component extracellular region extracellular space Biological process pattern specification process odontogenesis of dentin-containing tooth hair follicle morphogenesis mammary gland bud morphogenesis negative regulation of cell fate commitment Wnt signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of Wnt signaling pathway BMP signaling pathway negative regulation of BMP signaling pathway negative regulation of myoblast differentiation negative regulation of determination of dorsal identity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25928 66042 Ensembl ENSG00000171243 ENSMUSG00000036169 UniProt Q6X4U4 Q9CQN4 RefSeq (mRNA) NM_015464 NM_025312 RefSeq (protein) NP_056279 NP_079588 Location (UCSC) Chr 7: 16.46 – 16.53 Mb Chr 12: 36.36 – 36.37 Mb PubMed search
Wikidata
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Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.

Function

This gene is a member of the sclerostin family and encodes Uterine sensitization-associated gene-1 (USAG-1), an N-glycosylated, secreted protein with a C-terminal, cystine, knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.

Inhibition of USAG-1 is of interest as a potential means of stimulating tooth regeneration for dentistry.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000171243 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000036169 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: SOSTDC1 sclerostin domain containing 1".
6. Murashima-Suginami A, Kiso H, Tokita Y, Mihara E, Nambu Y, Uozumi R, Tabata Y, Bessho K, Takagi J, Sugai M, Takahashi K (February 2021). "Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling". Science Advances. 7 (7). doi:10.1126/sciadv.abf1798. PMC 7880588. PMID 33579703.
7. Ravi V, Murashima-Suginami A, Kiso H, Tokita Y, Huang CL, Bessho K, Takagi J, Sugai M, Tabata Y, Takahashi K (March 2023). "Advances in tooth agenesis and tooth regeneration". Regenerative Therapy. 22: 160–168. doi:10.1016/j.reth.2023.01.004. PMC 9931762. PMID 36819612.
8. "World's 1st 'tooth regrowth' medicine moves toward clinical trials in Japan". Mainichi. 12 June 2023.

Further reading

• Yanagita M (June 2005). "BMP antagonists: their roles in development and involvement in pathophysiology". Cytokine & Growth Factor Reviews. 16 (3): 309–17. doi:10.1016/j.cytogfr.2005.02.007. PMID 15951218.
• Laurikkala J, Kassai Y, Pakkasjärvi L, Thesleff I, Itoh N (December 2003). "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot". Developmental Biology. 264 (1): 91–105. doi:10.1016/j.ydbio.2003.08.011. PMID 14623234.
• Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T (April 2004). "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney". Biochemical and Biophysical Research Communications. 316 (2): 490–500. doi:10.1016/j.bbrc.2004.02.075. PMID 15020244.
• Goto M, Eddy EM (October 2004). "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20". The Journal of Biological Chemistry. 279 (40): 42128–38. doi:10.1074/jbc.M403190200. PMID 15280373.

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