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SPINLW1

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Protein-coding gene in the species Homo sapiens
EPPIN
Identifiers
AliasesEPPIN, CT71, CT72, SPINLW1, WAP7, WFDC7, dJ461P17.2, epididymal peptidase inhibitor
External IDsOMIM: 609031; MGI: 2684968; HomoloGene: 128601; GeneCards: EPPIN; OMA:EPPIN - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)
Chromosome 20 (human)Genomic location for EPPINGenomic location for EPPIN
Band20q13.12Start45,540,626 bp
End45,547,752 bp
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)
Chromosome 2 (mouse)Genomic location for EPPINGenomic location for EPPIN
Band2|2 H3Start164,421,439 bp
End164,427,367 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • corpus epididymis

  • left testis

  • buccal mucosa cell

  • epithelium of bronchus

  • bronchial epithelial cell

  • tail of epididymis

  • mucosa of paranasal sinus

  • olfactory zone of nasal mucosa

  • gonad
Top expressed in
  • testicle

  • spermatocyte

  • urinary bladder

  • lung

  • spermatid

  • ovary

  • adrenal gland

  • uterus

  • white adipose tissue

  • stomach
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57119

209351

Ensembl

ENSG00000101448

ENSMUSG00000074595

UniProt

O95925

Q3UW55

RefSeq (mRNA)

NM_181502
NM_001302861
NM_020398

NM_001033240
NM_001177848

RefSeq (protein)

NP_001289790
NP_065131
NP_001185915

NP_001028412
NP_001171319

Location (UCSC)Chr 20: 45.54 – 45.55 MbChr 2: 164.42 – 164.43 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Eppin is a protein that in humans is encoded by the SPINLW1 gene.

This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000101448Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000074595Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Richardson RT, Sivashanmugam P, Hall SH, Hamil KG, Moore PA, Ruben SM, French FS, O'Rand M (Jun 2001). "Cloning and sequencing of human Eppin: a novel family of protease inhibitors expressed in the epididymis and testis". Gene. 270 (1–2): 93–102. doi:10.1016/S0378-1119(01)00462-0. PMID 11404006.
  6. Clauss A, Lilja H, Lundwall A (Nov 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem J. 368 (Pt 1): 233–42. doi:10.1042/BJ20020869. PMC 1222987. PMID 12206714.
  7. ^ "Entrez Gene: SPINLW1 serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)".

Further reading


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