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SR1 RNA

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In molecular biology, the SR1 RNA is a small RNA (sRNA) produced by species of Bacillus and closely related bacteria. It is a dual-function RNA which acts both as a protein-coding RNA and as a regulatory sRNA.

SR1 RNA is involved in the regulation of arginine catabolism. SR1 RNA binds to complementary stretches of ahrC mRNA (also known as argR and inhibits translation. AhrC endodes an arginine repressor protein which represses synthesis of arginine biosynthetic enzymes and activates arginine catabolic enzymes via regulation of the rocABC and rocDEF operons.

In addition to acting as a sRNA, SR1 also encodes a small peptide, SR1P. SR1P binds to glyceraldehyde-3-phosphate dehydrogenase (GapA) and stabilises the gapA operon mRNAs.

SR1 expression is regulated by CcpA and CcpN.

See also

References

  1. Gimpel M, Preis H, Barth E, Gramzow L, Brantl S (October 13, 2012). "SR1—a small RNA with two remarkably conserved functions". Nucleic Acids Research. 40 (22): 11659–11672. doi:10.1093/nar/gks895. PMC 3526287. PMID 23034808.
  2. Heidrich N, Moll I, Brantl S (2007). "In vitro analysis of the interaction between the small RNA SR1 and its primary target ahrC mRNA". Nucleic Acids Research. 35 (13): 4331–4346. doi:10.1093/nar/gkm439. PMC 1935000. PMID 17576690.
  3. Heidrich N, Chinali A, Gerth U, Brantl S (October 2006). "The small untranslated RNA SR1 from the Bacillus subtilis genome is involved in the regulation of arginine catabolism". Molecular Microbiology. 62 (2): 520–536. doi:10.1111/j.1365-2958.2006.05384.x. PMID 17020585.
  4. North AK, Smith MC, Baumberg S (August 1, 1989). "Nucleotide sequence of a Bacillus subtilis arginine regulatory gene and homology of its product to the Escherichia coli arginine repressor". Gene. 80 (1): 29–38. doi:10.1016/0378-1119(89)90247-3. PMID 2507400.
  5. Czaplewski LG, North AK, Smith MC, Baumberg S, Stockley PG (January 1992). "Purification and initial characterization of AhrC: the regulator of arginine metabolism genes in Bacillus subtilis". Mol. Microbiol. 6 (2): 267–275. doi:10.1111/j.1365-2958.1992.tb02008.x. PMID 1312212. S2CID 3219261.
  6. Dennis CA, Glykos NM, Parsons MR, Phillips SE (March 2002). "The structure of AhrC, the arginine repressor/activator protein from Bacillus subtilis". Acta Crystallographica Section D. 58 (Pt 3): 421–430. doi:10.1107/s0907444901021692. PMID 11856827.
  7. Gimpel M, Heidrich N, Mäder U, Krügel H, Brantl S (May 2010). "A dual-function sRNA from B. subtilis: SR1 acts as a peptide encoding mRNA on the gapA operon" (PDF). Molecular Microbiology. 76 (4): 990–1009. doi:10.1111/j.1365-2958.2010.07158.x. PMID 20444087.
  8. Licht A, Preis S, Brantl S (October 2005). "Implication of CcpN in the regulation of a novel untranslated RNA (SR1) in Bacillus subtilis". Molecular Microbiology. 58 (1): 189–206. doi:10.1111/j.1365-2958.2005.04810.x. PMID 16164558. S2CID 29961832.
  9. Licht A, Brantl S (October 2009). "The transcriptional repressor CcpN from Bacillus subtilis uses different repression mechanisms at different promoters". Journal of Biological Chemistry. 284 (44): 30032–30038. doi:10.1074/jbc.M109.033076. PMC 2781557. PMID 19726675.
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