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STARD10
Identifiers
Aliases	STARD10, NY-CO-28, PCTP2, SDCCAG28, CGI-52, StAR related lipid transfer domain containing 10
External IDs	OMIM: 617382; MGI: 1860093; HomoloGene: 4841; GeneCards: STARD10; OMA:STARD10 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.4 Start 72,754,729 bp End 72,794,047 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E2 Start 100,966,293 bp End 100,995,833 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver mucosa of transverse colon body of pancreas left adrenal cortex right testis left testis right adrenal cortex rectum olfactory zone of nasal mucosa mucosa of ileum Top expressed in left lobe of liver epithelium of stomach pyloric antrum crypt of lieberkuhn of small intestine seminiferous tubule gallbladder mucous cell of stomach right kidney spermatid human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lipid binding phospholipid transporter activity Cellular component cytoplasm cell projection cytosol microvillus membrane intercellular canaliculus motile cilium cilium Biological process bile acid secretion positive regulation of peroxisome proliferator activated receptor signaling pathway lipid transport phosphatidylcholine biosynthetic process phospholipid transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10809 56018 Ensembl ENSG00000214530 ENSMUSG00000030688 UniProt Q9Y365 Q9JMD3 RefSeq (mRNA) NM_006645 NM_019990 NM_001360460 RefSeq (protein) NP_006636 NP_064374 NP_001347389 Location (UCSC) Chr 11: 72.75 – 72.79 Mb Chr 7: 100.97 – 101 Mb PubMed search
Wikidata
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StAR-related lipid transfer protein 10 (STARD10) or PCTP-like protein is a lipid transfer protein that in humans is encoded by the STARD10 gene. The protein derives its name from the fact that the molecule contains a START domain. As part of the StarD2 subfamily, StarD10 can transport the lipids phosphatidylcholine and phosphatidylethanolamine between membranes in solution. Casein kinase II phosphorylates the protein on its serine at position 184.

The function of StarD10 in the cell is not yet understood. Its expression is associated with cancer, but the nature of its role is unclear. Most recent data indicate that loss of StarD10 expression in breast cancer is associated with poor outcomes in patients.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000214530 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030688 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721. S2CID 916155.
6. "Entrez Gene: STARD10 START domain containing 10".
7. Olayioye MA, Vehring S, Müller P, Herrmann A, Schiller J, Thiele C, Lindeman GJ, Visvader JE, Pomorski T (July 2005). "StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein". The Journal of Biological Chemistry. 280 (29): 27436–42. doi:10.1074/jbc.M413330200. PMID 15911624.
8. Olayioye MA, Buchholz M, Schmid S, Schöffler P, Hoffmann P, Pomorski T (August 2007). "Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity". The Journal of Biological Chemistry. 282 (31): 22492–8. doi:10.1074/jbc.M701990200. PMID 17561512.
9. Murphy NC, Biankin AV, Millar EK, McNeil CM, O'Toole SA, Segara D, Crea P, Olayioye MA, Lee CS, Fox SB, Morey AL, Christie M, Musgrove EA, Daly RJ, Lindeman GJ, Henshall SM, Visvader JE, Sutherland RL (March 2010). "Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status". International Journal of Cancer. 126 (6): 1445–53. doi:10.1002/ijc.24826. PMID 19676041. S2CID 24623598.

Further reading

• Olayioye MA, Buchholz M, Schmid S, Schöffler P, Hoffmann P, Pomorski T (August 2007). "Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity". The Journal of Biological Chemistry. 282 (31): 22492–8. doi:10.1074/jbc.M701990200. PMID 17561512.
• Olayioye MA, Vehring S, Müller P, Herrmann A, Schiller J, Thiele C, Lindeman GJ, Visvader JE, Pomorski T (July 2005). "StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein". The Journal of Biological Chemistry. 280 (29): 27436–42. doi:10.1074/jbc.M413330200. PMID 15911624.
• Tabibiazar R, Wagner RA, Liao A, Quertermous T (December 2003). "Transcriptional profiling of the heart reveals chamber-specific gene expression patterns". Circulation Research. 93 (12): 1193–201. doi:10.1161/01.RES.0000103171.42654.DD. PMID 14576202. S2CID 23716150.
• Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

• Genes on human chromosome 11