Scytalone dehydratase - Misplaced Pages

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming). This enzyme is also called scytalone 7,8-hydro-lyase.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1IDP, 1STD, 2STD, 3STD, 4STD, 5STD, 6STD, and 7STD.

References

Butler MJ, Lazarovits G, Higgins VJ, Lachance MA (1988). "Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi". Exp. Mycol. 12 (4): 367–376. doi:10.1016/0147-5975(88)90028-X.
Tajima S, Kubo Y, Furusawa I, Shishiyama J (1989). "Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus". Exp. Mycol. 13: 69–76. doi:10.1016/0147-5975(89)90009-1.
Wheeler MH; Greenblatt GA (1988). "The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease". Exp. Mycol. 12 (2): 151–160. doi:10.1016/0147-5975(88)90004-7.

v t e Carbon–oxygen lyases (EC 4.2) (primarily dehydratases)
4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase
4.2.2: Acting on polysaccharides	Hyaluronate lyase Pectin lyase
4.2.3: Acting on phosphates	Threonine synthase
4.2.99: Other	Carboxymethyloxysuccinate lyase Hydroperoxide lyase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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